Radio frequency-mediated local thermotherapy for destruction of pancreatic tumors using Ni-Au core-shell nanowires

被引：13

作者：

Hopkins, Xiaoping ^{[1
]}

Gill, Waqas Amin ^{[2
]}

Kringel, Rosemarie ^{[1
]}

Wang, Guankui ^{[3
]}

Hass, Jamie ^{[4
]}

Acharya, Suresh ^{[3
]}

Park, Jungrae ^{[5
]}

Jeon, In Tak ^{[6
]}

An, Boo Hyun ^{[2
]}

Lee, Ji Sung ^{[2
]}

Ryu, Jong Eun ^{[7
]}

Hill, Rod ^{[3
]}

McIlroy, David ^{[4
]}

Kim, Young Keun ^{[6
]}

Choi, Daniel S. ^{[2
]}

机构：

[1] Univ Idaho, Dept Chem & Mat Engn, Moscow, ID 83844 USA

[2] Masdar Inst Sci & Technol, Dept Mech & Mat Engn, POB 54224, Abu Dhabi, U Arab Emirates

[3] Univ Idaho, Dept Anim & Vet Sci, Moscow, ID 83844 USA

[4] Univ Idaho, Dept Phys, Moscow, ID 83844 USA

[5] MinoTech Engn Inc, Charlton, MA 01507 USA

[6] Korea Univ, Dept Mat Sci & Engn, Seoul 02841, South Korea

[7] Indiana Univ Purdue Univ, Purdue Sch Engn & Technol, Dept Mech Engn, Indianapolis, IN 46202 USA

来源：

NANOTECHNOLOGY | 2017年 / 28卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

RF-mediated thermotherapy; magnetic core-shell nanowire; RF radiation; cancer; NEAR-INFRARED LIGHT; MAGNETIC NANOWIRES; SILICON NANOWIRES; NICKEL NANOWIRES; CANCER-THERAPY; REMOTE-CONTROL; HYPERTHERMIA; NANOPARTICLES; CELLS; FIELD;

D O I：

10.1088/1361-6528/28/3/03LT01

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

We present a novel method of radio frequency (RF)-mediated thermotherapy in tumors by remotely heating nickel (Ni)-gold (Au) core-shell nanowires (CSNWs). Ectopic pancreatic tumors were developed in nude mice to evaluate the thermotherapeutic effects on tumor progression. Tumor ablation was produced by RF-mediated thermotherapy via activation of the paramagnetic properties of the Ni-Au CSNWs. Histopathology demonstrated that heat generated by RF irradiation caused significant cellular death with pyknotic nuclei and nuclear fragmentation dispersed throughout the tumors. These preliminary results suggest that thermotherapy ablation induced via RF activation of nanowires provides a potential alternative therapy for cancer treatment.

引用

页数：9

共 20 条

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Jeon, In Tak
Cho, Moon Kyu
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An, Boo Hyun
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Kringel, Rosemarie
Choi, Daniel S.
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Gill, Waqas Amin
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Kim, Young Keun
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PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE, 2017, 214 (06):
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JOURNAL OF PHYSICAL CHEMISTRY C, 2019, 123 (32): : 20037 - 20043
[4] Optical Absorption Properties of Fe/Co/Ni-Au Core-Shell Nanostructures
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ADVANCES IN BASIC SCIENCES (ICABS 2019), 2019, 2142
[5] Dumbbell to Core-Shell Structure Transformation of Ni-Au Nanoparticle Driven by External Stimuli
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[8] Broadband Meta-Absorber with Au/Ni Core-Shell Nanowires for Solar Vapor Generator
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ADVANCED SUSTAINABLE SYSTEMS, 2021, 5 (03)
[9] Stability of Core-Shell Nanoparticles for Catalysis at Elevated Temperatures: Structural inversion in the Ni-Au System Observed at Atomic Resolution
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