ACEIs and ARBs and Their Correlation with COVID-19: A Review

被引：20

作者：

Shewasinad Yehualashet, Awgichew ^{[1
]}

Fentik Belachew, Teshome ^{[2
]}

机构：

[1] Debre Berhan Univ, Dept Pharm, Coll Hlth Sci, Pharmacol & Toxicol Unit, POB 445, Debre Berhan, Ethiopia

[2] Debre Birhan Hlth Sci Coll, Dept Pharm, Debre Birhan, Ethiopia

来源：

INFECTION AND DRUG RESISTANCE | 2020年 / 13卷

关键词：

coronavirus; COVID-19; ACEIs; ARBs; RENIN-ANGIOTENSIN SYSTEM; CONVERTING ENZYME 2; RECEPTOR BLOCKERS; CORONAVIRUS; INHIBITORS; METAANALYSIS; THERAPY; TMPRSS2; SARS;

D O I：

10.2147/IDR.S264882

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Although some animal studies suggested that the use of ACEIs/ARBs could contribute for the prevention and treatment of the effects of the COVID-19 infection, there are also contradictory scenarios indicating that their use may exacerbate the deleterious conditions of the infection. As a result of the paradoxical issue of using ACEIs/ARBs during COVID-19, it is still an area requiring extended investigation to prove. Additionally, a trial evidence of their efficacy and the possible benefit risk analysis of these conventional drugs during COVID-19 in connection with other comorbidities like hypertension, heart failure, and renal disease associated with diabetes should also be addressed.

引用

页码：3217 / 3224

页数：8

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