Co-existence of Philadelphia chromosome positive acute megakaryoblastic and B-lymphoblastic mixed blast crisis of chronic myeloid leukemia with chronic lymphocytic leukemia

被引：1
|
作者：
Colla, S
Sammarelli, G
Crugnola, M
Ascani, S
Sabbatini, E
Bonomini, S
Hojden, M
Craviotto, L
De Celis, I
Morandi, F
Caramatti, C
Rizzoli, V
Giuliani, N
机构：
[1] Univ Parma, Chair Hematol, I-43100 Parma, Italy
[2] Univ Parma, BMT Unit, I-43100 Parma, Italy
[3] Univ Bologna, Dept Pathol, Bologna, Italy
来源：
EUROPEAN JOURNAL OF HAEMATOLOGY | 2004年 / 72卷 / 05期
关键词：
megakaryoblast; chronic myeloid leukemia; chronic lymphocytic leukemia; Philadelphia chromosome; imatinib;
D O I：
10.1111/j.1600-0609.2004.00222.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In this study, we describe an extremely rare case of coexistence of a Philadelphia chromosome positive acute megakaryoblastic and B-lymphoblastic mixed blast crisis of chronic rnyeloid leukemia with chronic lymphocytic leukemia. A morphological, immunophenotypical and cytogenetic study has been performed to characterize the case and in order to identify the origin of two disorders. After the failure of the conventional therapy, the patient was treated with Imatinib with a complete hematological and cytogenetic response and a marked reduction of bone marrow fibrosis.
引用
收藏
页码：361 / 365
页数：5
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