Kruppel-like factor 2 inhibits hepatocarcinogenesis through negative regulation of the Hedgehog pathway

被引：30

作者：

Lin, JinBo ^{[1
]}

Tan, Huifang ^{[2
]}

Nie, Yingjie ^{[3
]}

Wu, Dongwen ^{[4
]}

Zheng, Weiji ^{[1
]}

Lin, Wensong ^{[1
]}

Zhu, Zheng ^{[1
]}

Yang, Bing ^{[1
]}

Chen, Xiaoliang ^{[5
]}

Chen, Tao ^{[2
,3
]}

机构：

[1] Zunyi Med Univ, Affiliated Longgang Hosp, Longgang Cent Hosp Shenzhen, Shenzhen, Peoples R China

[2] Guangzhou Med Univ, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China

[3] Guizhou Prov Peoples Hosp, Clin Res Lab Ctr, Guiyang, Guizhou, Peoples R China

[4] Cent South Univ, Xiangya Hosp 3, Changsha, Hunan, Peoples R China

[5] Shenzhen Guangming Dist Ctr Dis Prevent & Control, Shenzhen, Peoples R China

来源：

CANCER SCIENCE | 2019年 / 110卷 / 04期

关键词：

HDAC1; Hedgehog signaling; hepatocellular carcinoma; intrahepatic metastasis; Kruppel-like factor 2; NONCODING RNA ANRIL; CELL LUNG-CANCER; HEPATOCELLULAR-CARCINOMA; DOWN-REGULATION; PROLIFERATION; MIGRATION; INVASION; GROWTH; KLF2; TRANSCRIPTION;

D O I：

10.1111/cas.13961

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. The most important reason for the occurrence of HCC is hepatitis C or B infection. Moreover, genetic factors play an important role in the tumorigenesis of HCC. Here, we demonstrated that Kruppel-like factor 2 (KLF2) expression was downregulated in HCC samples compared with adjacent tissues. Additionally, KLF2 was shown to inhibit the growth, migration and colony-formation ability of liver cancer cells. Further mechanistic studies revealed that KLF2 can compete with Gli1 for interaction with HDAC1 and restrains Hedgehog signal activation. Together, our results suggest that KLF2 has potential as a diagnostic biomarker and therapeutic target for the treatment of HCC.

引用

页码：1220 / 1231

页数：12

共 50 条

[1] Kruppel-like factor 2 inhibits hepatocarcinogenesis through negative regulation of the Hedgehog pathway
Nie, Y.
Lin, J.
Tan, H.
Wu, D.
Zheng, W.
Lin, W.
Zhu, Z.
Yang, B.
Chen, X.
Chen, T.
EUROPEAN JOURNAL OF IMMUNOLOGY, 2019, 49 : 25 - 26
[2] Regulation of gluconeogenesis by Kruppel-like factor 15
Gray, Susan
Wang, Baiqiu
Orihuela, Yvette
Hong, Eun-Gyoung
Fisch, Sudeshna
Haldar, Saptarsi
Cline, Gary W.
Kim, Jason K.
Peroni, Odile D.
Kahn, Barbara B.
Jain, Mukesh K.
CELL METABOLISM, 2007, 5 (04) : 305 - 312
[3] Opposing effects of Kruppel-like factor 4 (gut-enriched Kruppel-like factor) and Kruppel-like factor 5 (intestinal-enriched Kruppel-like factor) on the promoter of the Kruppel-like factor 4 gene
Dang, DT
Zhao, WD
Mahatan, CS
Geiman, DE
Yang, VW
NUCLEIC ACIDS RESEARCH, 2002, 30 (13) : 2736 - 2741
[4] Regulation of DNA repair by Kruppel-like factor 8
Lu, Heng
Hu, Liu
Li, Tianshu
Mukherjee, Debarati
Lahiri, Satadru
Wason, Melissa
Yu, Lin
Zhao, Jihe
CANCER RESEARCH, 2012, 72
[5] Kruppel-like factor 9 promotes neuroblastoma differentiation via targeting the sonic hedgehog signaling pathway
Chen, Sheng
Gu, Song
Xu, Min
Mei, Dongyu
Xiao, Yongtao
Chen, Kai
Yan, Zhilong
PEDIATRIC BLOOD & CANCER, 2020, 67 (03)
[6] Regulation of Endothelial Metabolism by Kruppel-like Factor 2 and Shear Stress
Doddaballapur, Anuradha
Michalik, Katharina
Houtkooper, Riekelt H.
You, Xintian
Chen, Wei
Dimmeler, Stefanie
Boon, Reinier A.
CIRCULATION, 2013, 128 (22)
[7] The Role of Kruppel-like Factor 6 in Prolidase Regulation
Eni-aganga, Ireti
Lanaghan, Zeljka
Muthukumar
Dash, Chandravanu
Pandhare, Jui
FASEB JOURNAL, 2021, 35
[8] Characterization of the structure and regulation of the murine gene encoding gut-enriched Kruppel-like factor (Kruppel-like factor 4)
Mahatan, CS
Kaestner, KH
Geiman, DE
Yang, VW
NUCLEIC ACIDS RESEARCH, 1999, 27 (23) : 4562 - 4569
[9] Transcriptional regulation of γ- and ε-globin genes by basic Kruppel-like factor
Ma, XY
Wang, MJ
Qu, XH
Xing, GC
Zhu, YP
He, FC
ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2003, 35 (03): : 271 - 276
[10] Adriamycin inhibits embryonic development in zebrafish through downregulation of Kruppel-like factor4
Akthar, I. Syeda Thabassum
Pichiah, P. B. Tirupathi
Arunachalam, Sankarganesh
Raja, Sudhakaran
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2019, 33 (01)

← 1 2 3 4 5 →