Mechanisms of action of new antiepileptic drugs

被引：73
|
作者：
Macdonald, RL
Greenfield, LJ
机构：
[1] UNIV MICHIGAN, MED CTR, DEPT NEUROL, ANN ARBOR, MI 48109 USA
[2] UNIV MICHIGAN, MED CTR, DEPT PHYSIOL, ANN ARBOR, MI 48109 USA
来源：
CURRENT OPINION IN NEUROLOGY | 1997年 / 10卷 / 02期
关键词：
D O I：
10.1097/00019052-199704000-00009
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Many new antiepileptic drugs have been developed to treat seizure disorders. The established antiepileptic drugs reduce neuronal excitability by promoting sodium channel inactivation, inhibiting T-type calcium channels, or enhancing gamma-aminobutyric acid type A receptor-mediated inhibition. Several of the newer agents employ similar mechanisms, whereas others may enhance gamma-aminobutyric acid-ergic inhibitory systems or inhibit glutamatergic excitatory neurotransmission, and may be neuroprotective or antiepileptogenic.
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页码：121 / 128
页数：8
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