Probing the Dynamic Structure and Function of Intracellular Loop 2 in Structurally Cognate GPCRs

被引:1
|
作者
Shan, Jufang [1 ]
Mehler, Ernest L. [1 ]
Weinstein, Harel [1 ,2 ]
机构
[1] Cornell Univ, Dept Physiol & Biophys, Weill Med Coll, New York, NY 10021 USA
[2] Cornell Univ, Weill Med Coll, HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsau, New York, NY 10021 USA
关键词
D O I
10.1016/j.bpj.2008.12.2200
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
2214-Pos
引用
收藏
页码:429A / 430A
页数:2
相关论文
共 50 条
  • [1] Probing the Structural Determinants for the Function of Intracellular Loop 2 in Structurally Cognate G-Protein-Coupled Receptors
    Shan, Jufang
    Weinstein, Harel
    Mehler, Ernest L.
    BIOCHEMISTRY, 2010, 49 (50) : 10691 - 10701
  • [2] Structure and function of the third intracellular loop of the 5-hydroxytryptamine2A receptor:: The third intracellular loop is α-helical and binds purified arrestins
    Gelber, EI
    Kroeze, WK
    Willins, DL
    Gray, JA
    Sinar, CA
    Hyde, EG
    Gurevich, V
    Benovic, J
    Roth, BL
    JOURNAL OF NEUROCHEMISTRY, 1999, 72 (05) : 2206 - 2214
  • [3] Structure-function analysis of angiotensin II type 2 receptor third intracellular loop
    Lehtonen, JYA
    Daviet, L
    Horiuchi, M
    Dzau, VJ
    CIRCULATION, 1998, 98 (17) : 741 - 741
  • [4] Identification of an agonist binding site motif that regulates biased signaling of GPCRs through altered conformations of intracellular loop 2
    Soto, Marta Sanchez
    Verma, Ravi Kumar
    Willette, Blair K. A.
    Gonye, Elizabeth C.
    Moore, Annah M.
    Chun, Lani S.
    Moritz, Amy E.
    Yano, Hideaki
    Free, R. Benjamin
    Shi, Lei
    Sibley, David R.
    FASEB JOURNAL, 2019, 33
  • [5] Intracellular Ca2+ stores -: Structure and function
    Kostyuk, PG
    JOURNAL OF NEUROCHEMISTRY, 1998, 71 : S3 - S3
  • [6] Evidence of the Importance of the First Intracellular Loop of Prokineticin Receptor 2 in Receptor Function
    Abreu, Ana Paula
    Noel, Sekoni D.
    Xu, Shuyun
    Carroll, Rona S.
    Latronico, Ana Claudia
    Kaiser, Ursula B.
    MOLECULAR ENDOCRINOLOGY, 2012, 26 (08) : 1417 - 1427
  • [7] PROBING THE ROLE OF LOOP-2 IN RAS FUNCTION WITH UNNATURAL AMINO-ACIDS
    CHUNG, HH
    BENSON, DR
    CORNISH, VW
    SCHULTZ, PG
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (21) : 10145 - 10149
  • [8] Structure function analysis of FSH receptor intracellular loop1 interaction with APPL1.
    Dias, James
    Nechamen, Cheryl
    Thomas, Richard
    BIOLOGY OF REPRODUCTION, 2007, : 196 - 196
  • [9] The structure of the third intracellular loop of the muscarinic acetylcholine receptor M2 subtype
    Ichlyama, S
    Oka, Y
    Haga, K
    Kojima, S
    Tateishi, Y
    Shirakawa, M
    Haga, T
    FEBS LETTERS, 2006, 580 (01) : 23 - 26
  • [10] CALMODULIN, AN INTRACELLULAR CA-2+ MODULATOR PROTEIN - STRUCTURE AND FUNCTION
    KREBS, J
    SCHAFER, B
    GUERRINI, D
    HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE, 1983, 364 (04): : 346 - 346