Phase 1 Study of Trametinib and Neoadjuvant Chemoradiation (CRT) in Locally Advanced Rectal Cancer (LARC) with KRAS, BRAF, or NRAS Mutations

被引:0
|
作者
Wuthrick, E. J. [1 ]
Williams, T. M. [1 ]
Wei, L. [1 ]
Umar, H. [1 ]
Savysan, A. [1 ]
Mikhail, S. [1 ]
Ciombor, K. [1 ]
Noonan, A. [1 ]
Roychowdhury, S. [1 ]
El-Dika, S. [1 ]
Krishna, S. [1 ]
Upchurch, B. [1 ]
Arnold, M. [1 ]
Harzman, A. [1 ]
Abdel-Misih, S. [1 ]
Cirocco, W. [1 ]
Bekaii-Saab, T. [1 ]
Wu, C. [1 ]
机构
[1] Ohio State Univ, Columbus, OH 43210 USA
关键词
D O I
10.1016/j.ijrobp.2016.06.264
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
241
引用
收藏
页码:S107 / S108
页数:2
相关论文
共 50 条
  • [1] Phase I study of trametinib and neoadjuvant chemoradiation (CRT) in patients with locally advanced rectal cancers (LARC) that harbor KRAS, BRAF, or NRAS mutations
    Wu, Christina Sing-Ying
    Williams, Terence Marques
    Wei, Lai
    Umar, Hamida
    Savysan, Arsen
    Mikhail, Sameh
    Ciombor, Kristen Keon
    Noonan, Anne M.
    Roychowdhury, Sameek
    El-Dika, Samer S.
    Krishna, Somashekar
    Upchurch, Bennie
    Arnold, Mark
    Harzman, Alan
    Abdel-Misih, Sherif
    Cirocco, William
    Bekaii-Saab, Tanios S.
    Wuthrick, Evan John
    JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (15)
  • [2] Phase I study of trametinib with neoadjuvant chemoradiation (CRT) in patients with locally advanced rectal cancers (LARC).
    Wu, Christina Sing-Ying
    Williams, Terence Marques
    Wei, Lai
    Umar, Hamida
    Mikhail, Sameh
    Ciombor, Kristen Keon
    Chan, Emily
    Noonan, Anne M.
    Roychowdhury, Sameek
    El-Dika, Samer S.
    Krishna, Somashekar
    McCarthy, Sean T.
    Arnold, Mark
    Harzman, Alan
    Abdel-Misih, Sherif
    Cirocco, William
    Traugott, Amber
    Bekaii-Saab, Tanios S.
    Wuthrick, Evan John
    JOURNAL OF CLINICAL ONCOLOGY, 2017, 35
  • [3] Phase I study of neoadjuvant 5-fluorouracil (5FU) chemoradiation (CRT) and trametinib in patients with locally advanced rectal cancers (LARC)
    Wu, Christina Sing-Ying
    Williams, Terence M.
    Wei, Lai
    Umar, Hamida
    Mikhail, Sameh
    Ciombor, Kristen Keon
    Noonan, Anne M.
    Roychowdhury, Sameek
    El-Dika, Samer S.
    Krishna, Somashekar
    Upchurch, Bennie
    McCarthy, Sean T.
    Arnold, Mark
    Harzman, Alan
    Abdel-Misih, Sherif
    Cirocco, William
    Traugott, Amber
    Bekaii-Saab, Tanios S.
    Wuthrick, Evan John
    JOURNAL OF CLINICAL ONCOLOGY, 2017, 35 (04)
  • [4] Phase I Trial of Trametinib with Neoadjuvant Chemoradiation in Patients with Locally Advanced Rectal Cancer
    Wu, Christina
    Williams, Terence M.
    Robb, Ryan
    Webb, Amy
    Wei, Lai
    Chen, Wei
    Mikhail, Sameh
    Ciombor, Kristen K.
    Cardin, Dana B.
    Timmers, Cynthia
    Krishna, Somashekar G.
    Arnold, Mark
    Harzman, Alan
    Abdel-Misih, Sherif
    Roychowdhury, Sameek
    Bekaii-Saab, Tanios
    Wuthrick, Evan
    CLINICAL CANCER RESEARCH, 2020, 26 (13) : 3117 - 3125
  • [5] Impact of age on efficacy of neoadjuvant chemoradiotherapy (CRT) in locally advanced rectal cancer (LARC)
    Calderillo, G.
    Herrera, M.
    Lopez, H.
    Diaz, C.
    Padilla, A.
    Ruiz-Garcia, E.
    Trejo, E.
    ANNALS OF ONCOLOGY, 2016, 27 : 38 - 38
  • [6] Chemotherapy first, followed by chemoradiation (CRT) and then surgery, in the management of locally advanced rectal cancer (LARC)
    Cercek, Andrea
    Goodman, Karyn A.
    Hajj, Carla
    Weisberger, Emily
    Segal, Neil Howard
    Reidy, Diane Lauren
    Stadler, Zsofia Kinga
    Wu, Abraham Jing-Ching
    Weiser, Martin R.
    Paty, Philip
    Guillem, Jose G.
    Nash, Garrett Michael
    Temple, Larissa K. F.
    Garcia-Aguilar, Julio
    Saltz, Leonard
    JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (15)
  • [7] Molecular diagnosis of pathologic complete response (pCR) to neoadjuvant chemoradiation therapy (CRT) in patients with locally advanced rectal cancer (LARC)
    Chen, Zhenbin
    Li, Wenyan
    Garcia-Aguilar, Julio
    JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, 2010, 211 (03) : S13 - S14
  • [8] Neoadjuvant chemoradiation in locally advanced rectal cancer: Results of a phase II study
    Delrio, P
    Avallone, A
    Guida, C
    Marone, P
    Petrillo, A
    Tatangelo, F
    Di Marzo, M
    Scala, D
    Parisi, V
    ANNALS OF SURGICAL ONCOLOGY, 2004, 11 (02) : S115 - S115
  • [9] Neoadjuvant chemoradiation in locally advanced rectal cancer: Results of a phase II study
    P. Delrio
    A. Avallone
    C. Guida
    P. Marone
    A. Petrillo
    F. Tatangelo
    M. Di Marzo
    D. Scala
    V. Parisi
    Annals of Surgical Oncology, 2004, 11 : S115 - S115
  • [10] NEOADJUVANT CHEMORADIATION IN LOCALLY ADVANCED RECTAL CANCER
    Meireles, P.
    Fonte, D.
    Costa, A.
    Almeida, D.
    Reis Lima Marques, M.
    Sarmento, C.
    Rey, C.
    Pinto, G.
    RADIOTHERAPY AND ONCOLOGY, 2011, 99 : S396 - S396