Plasma persistence of 2-aminothiazoline-4-carboxylic acid in rat system determined by liquid chromatography tandem mass spectrometry

被引：15

作者：

Petrikovics, Ilona ^{[1
]}

Yu, Jorn C. C. ^{[2
]}

Thompson, David E. ^{[1
]}

Jayanna, Prashanth ^{[1
]}

Logue, Brian A. ^{[3
]}

Nasr, Jessica ^{[1
]}

Bhandari, Raj K. ^{[3
]}

Baskin, Steven I. ^{[4
]}

Rockwood, Gary ^{[4
]}

机构：

[1] Sam Houston State Univ, Dept Chem, Huntsville, TX 77341 USA

[2] Sam Houston State Univ, Coll Criminal Justice, Forens Sci Program, Huntsville, TX 77341 USA

[3] S Dakota State Univ, Dept Chem & Biochem, Brookings, SD 57007 USA

[4] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA

来源：

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2012年 / 891卷

基金：

美国国家卫生研究院;

关键词：

Diagnostic biomarker; Forensic biomarker; Cyanide exposure; 2-Aminothiazoline-4-carboxylic acid (ATCA); LC-MS/MS; CYANIDE EXPOSURE; URINE;

D O I：

10.1016/j.jchromb.2012.01.024

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

2-Aminothiazoline-4-carboxylic acid (ATCA) was intravenously injected to rats in order to investigate its plasma distribution. ATCA was extracted from plasma samples by solid phase extraction (SPE) and molecularly imprinted polymer stir bar sorption extraction (MIP-SBSE). Detection and quantification of ATCA were achieved by using liquid chromatography-tandem mass spectrometry (LC-MS/MS). It was found that the intravenously injected ATCA concentration quickly decreased to half within 2.5 h in the rat system. However, after 2.5 h, the concentration of ATCA in plasma stayed constant at least 5 folds above the endogenous ATCA level for more then 48 h. This finding can be used for evaluating ATCA's diagnostic and forensic value as a biomarker for cyanide exposure. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：81 / 84

页数：4

共 50 条

[1] Simultaneous quantification of 2-aminothiazoline-4-carboxylic acid and 2-aminothiazoline-4-oxoaminoethanoic acid utilizing chemical derivatization followed by liquid chromatography-tandem mass spectrometry
Nishio, Tadashi
Toukairin, Yoko
Hoshi, Tomoaki
Arai, Tomomi
Nogami, Makoto
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2024, 242
[2] Determination of the cyanide metabolite 2-aminothiazoline-4-carboxylic acid in urine and plasma by gas chromatography-mass spectrometry
Logue, BA
Kirschten, NP
Petrikovics, I
Moser, MA
Rockwood, GA
Baskin, SI
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2005, 819 (02): : 237 - 244
[3] Quantification of cyanide metabolite 2-aminothiazoline-4-carboxylic acid in postmortem dried blood spot samples by liquid chromatography-tandem mass spectrometry
Nishio, Tadashi
Toukairin, Yoko
Hoshi, Tomoaki
Arai, Tomomi
Nogami, Makoto
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2023, 1215
[4] Quantification of 2-aminothiazoline-4-carboxylic acid as a reliable marker of cyanide exposure using chemical derivatization followed by liquid chromatography-tandem mass spectrometry
Nishio, Tadashi
Toukairin, Yoko
Hoshi, Tomoaki
Arai, Tomomi
Nogami, Makoto
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2022, 207
[5] Determination of cyanide metabolite, 2-aminothiazoline-4-carboxylic acid, in urine by gas chromatography-mass spectrometry.
Logue, BA
Pieper, BJ
Petrikovics, I
Moser, MA
Baskin, SI
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2004, 227 : U94 - U94
[6] ANALYSIS OF THE CYANIDE METABOLITE 2-AMINOTHIAZOLINE-4-CARBOXYLIC ACID IN URINE BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY
LUNDQUIST, P
KAGEDAL, B
NILSSON, L
ROSLING, H
ANALYTICAL BIOCHEMISTRY, 1995, 228 (01) : 27 - 34
[7] Application of 2-Aminothiazoline-4-carboxylic Acid as a Forensic Marker of Cyanide Exposure
Ruiycka, Monika
Giebultowicz, Joanna
Fudalej, Marcin
Krajewski, Pawel
Wroczynski, Piotr
CHEMICAL RESEARCH IN TOXICOLOGY, 2017, 30 (02) : 516 - 523
[8] Spectrophotometric analysis of the cyanide metabolite 2-aminothiazoline-4-carboxylic acid (ATCA)
Baskin, Steven I.
Petrikovics, Ilona
Platoff, Gennady E.
Rockwood, Gary A.
Logue, Brian A.
TOXICOLOGY MECHANISMS AND METHODS, 2006, 16 (06) : 339 - 345
[9] Organ-distribution of the metabolite 2-aminothiazoline-4-carboxylic acid in a rat model following cyanide exposure
Petrikovics, Ilona
Thompson, David E.
Rockwood, Gary A.
Logue, Brian A.
Martin, Sarah
Jayanna, Prashanth
Yu, Jorn C. C.
BIOMARKERS, 2011, 16 (08) : 686 - 690
[10] RECiQ: A Rapid and Easy Method for Determining Cyanide Intoxication by Cyanide and 2-Aminothiazoline-4-carboxylic Acid Quantification in the Human Blood Using Probe Electrospray Ionization Tandem Mass Spectrometry
Hisatsune, Kazuaki
Murata, Tasuku
Ogata, Koretsugu
Hida, Minemasa
Ishii, Akira
Tsuchihashi, Hitoshi
Hayashi, Yumi
Zaitsu, Kei
ACS OMEGA, 2020, 5 (36): : 23351 - 23357

← 1 2 3 4 5 →