The Missing Link: How Exosomes and miRNAs can Help in Bridging Psychiatry and Molecular Biology in the Context of Depression, Bipolar Disorder and Schizophrenia

被引：62

作者：

Gruzdev, S. K. ^{[1
]}

Yakovlev, A. A. ^{[2
,3
]}

Druzhkova, T. A. ^{[3
]}

Guekht, A. B. ^{[3
,4
]}

Gulyaeva, N. V. ^{[2
,3
]}

机构：

[1] RUDN Univ, Inst Med, Miklukho Maklaya Str 6, Moscow 117198, Russia

[2] Russian Acad Sci, Inst Higher Nervous Act & Neurophysiol, Butlerova Str 5A, Moscow 117485, Russia

[3] Moscow Res & Clin Ctr Neuropsychiat, Moscow Healthcare Dept, Donskaya Str 43, Moscow 115419, Russia

[4] Russian Natl Res Med Univ, Ostrovitianov Str 1, Moscow 117997, Russia

来源：

CELLULAR AND MOLECULAR NEUROBIOLOGY | 2019年 / 39卷 / 06期

基金：

俄罗斯基础研究基金会;

关键词：

Exosomes; miRNA; Biomarker; Depression; Schizophrenia; Bipolar disorder; Psychiatry; TRANSCRANIAL MAGNETIC STIMULATION; MAJOR DEPRESSION; MICRORNA EXPRESSION; EXTRACELLULAR VESICLES; NEUROTROPHIC FACTOR; PERIPHERAL-BLOOD; CELL-PROLIFERATION; GENETIC VARIANT; MOOD DISORDERS; MESSENGER-RNA;

D O I：

10.1007/s10571-019-00684-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

MicroRNAs (miRNAs) only recently have been recognized as promising molecules for both fundamental and clinical neuroscience. We provide a literature review of miRNA biomarker studies in three most prominent psychiatric disorders (depression, bipolar disorder and schizophrenia) with the particular focus on depression due to its social and healthcare importance. Our search resulted in 191 unique miRNAs across 35 human studies measuring miRNA levels in blood, serum or plasma. 30 miRNAs replicated in more than one study. Most miRNAs targeted neuroplasticity and neurodevelopment pathways. Various limitations do not allow us to make firm conclusions on clinical potential of studied miRNAs. Based on our results we discuss the rationale for future research investigations of exosomal mechanisms to overcome methodological caveats both in studying etiology and pathogenesis, and providing an objective back-up for clinical decisions.

引用

页码：729 / 750

页数：22

共 2 条

[1] The Missing Link: How Exosomes and miRNAs can Help in Bridging Psychiatry and Molecular Biology in the Context of Depression, Bipolar Disorder and Schizophrenia
S. K. Gruzdev
A. A. Yakovlev
T. A. Druzhkova
A. B. Guekht
N. V. Gulyaeva
Cellular and Molecular Neurobiology, 2019, 39 : 729 - 750
[2] THE MISSING LINK HOW BIOLOGY CAN HELP PHILOSOPHY OF TECHNOLOGY COMPLETE ITS ONTOLOGICAL SHIFT
Sharon, Tamar
TIJDSCHRIFT VOOR FILOSOFIE, 2013, 75 (01) : 121 - 145

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