Comparison of the digene hybrid capture 2 and Roche cobas 4800 HPV tests for detection of CIN2+in a referral population in Japan

被引：10

作者：

Sasagawa, Toshiyuki ^{[1
]}

Maehama, Toshiyuki ^{[2
]}

Osaka, Yasuhiro ^{[1
]}

Sakamoto, Jinichi ^{[1
]}

Shibata, Takeo ^{[1
]}

Fujita, Satoko ^{[1
]}

Takakura, Masahiro ^{[1
]}

Takagi, Hiroaki ^{[1
]}

机构：

[1] Kanazawa Med Univ, Dept Obstet & Gynecol, Uchinada, Ishikawa, Japan

[2] Tomishiro Cent Hosp, Dept Obstet & Gynecol, Tomishiro City, Okinawa, Japan

来源：

JOURNAL OF MEDICAL VIROLOGY | 2018年 / 90卷 / 05期

关键词：

cervical cancer screening; cervical intraepithelial neoplasia (CIN); cobas HPV test (cobas); HPV genotyping; human papillomavirus (HPV); hybrid capture-2 (HC2); CERVICAL INTRAEPITHELIAL NEOPLASIA; HUMAN-PAPILLOMAVIRUS INFECTIONS; RISK HUMAN-PAPILLOMAVIRUS; CANCER; WOMEN; DNA; SAMPLES; ASSAYS;

D O I：

10.1002/jmv.25025

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

To examine validity of the hybrid capture-2 and cobas 4800 HPV tests, 396 women including 188 women visiting for cancer screening, and 208 referral cases were examined with both HPV tests and the liquid-based cervical Pap test. Concordant results between the HPV assays were observed in 333 cases (coincident rates; 84.1%, kappa value; 0.682). The sensitivity for CIN2+ was 98.6% (69/70) and 82.9% (58/70) for HC2 and cobas 4800 (McNemar's test; P=0.0026). The sensitivity for CIN3+ was 97.2% (35/36) and 83.3% (30/36) (Not significant, P=0.0736). The specificities for CIN2+ or CIN3+ did not differ between the tests. The HPV16, 52, 18, 31, and 58 were the most common types in CIN2+ cases. Reasonable sensitivity for HPV52, and cross-hybridization with some probable high-risk HPV type such as HPV82 explain the higher sensitivity of HC2 than cobas 4800 in detection of CIN2+ in a referral population in Japan.

引用

页码：972 / 980

页数：9

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