Asymmetric Synthesis of 2,3,4-Trisubstituted Piperidines

被引：7

作者：

Kriis, Kadri ^{[1
]}

Melnik, Triin ^{[1
]}

Lips, Kristiina ^{[1
]}

Juhanson, Ilona ^{[1
]}

Kaabel, Sandra ^{[1
]}

Jarving, Ivar ^{[1
]}

Kanger, Tonis ^{[1
]}

机构：

[1] Tallinn Univ Technol, Dept Chem, Akad Tee 15, EE-12618 Tallinn, Estonia

来源：

SYNTHESIS-STUTTGART | 2017年 / 49卷 / 03期

关键词：

organocatalysis; asymmetric catalysis; trisubstituted piperidines; aza-Michael addition; cyclization; SUBSTITUTED PIPERIDINES; CASCADE REACTION; FUNCTIONALIZED TETRAHYDROQUINOLINES; MICHAEL REACTION; CONSTRUCTION; 1-AZADIENES; DERIVATIVES;

D O I：

10.1055/s-0036-1588299

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two different organocatalytic approaches for the asymmetric synthesis of 2,3,4-trisubstituted piperidines were developed. Both approaches were based on an aza-Michael addition followed by cyclization and gave products in high enantiomeric excess.

引用

页码：604 / 614

页数：11

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