Nickel-catalyzed triarylamine synthesis: synthetic and mechanistic aspects

被引：19
|
作者：
Li, Xin-Le [1 ,2 ]
Wu, Wei [1 ,2 ]
Fan, Xin-Heng [1 ]
Yang, Lian-Ming [1 ]
机构：
[1] Chinese Acad Sci, Inst Chem, Key Lab Green Printing, BNLMS, Beijing 100190, Peoples R China
[2] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2014年 / 12卷 / 08期
基金：
中国国家自然科学基金;
关键词：
NI(II)-(SIGMA-ARYL) COMPLEX; AROMATIC AMINATIONS; ARYL CHLORIDES; N-ARYLATION; NITROGEN; WELL; DIARYLAMINES; COUPLINGS; CLEAVAGE; AMINES;
D O I：
10.1039/c3ob42053a
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An improved protocol was described for the amination of chloroarenes with diarylamines under NiCl2(PCy3)(2) catalysis in the presence of a Grignard reagent as base. This method fully suits bromo-/iodoarene substrates as well, and even is expanded to certain aryl tosylates. A preliminary investigation into the mechanism suggests that this amination reaction might proceed through Ni-I and Ni-III intermediates rather than via the usually expected Ni-0-Ni-II cycle.
引用
收藏
页码：1232 / 1236
页数：5
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