Morpholino-decorated long circulating polymeric micelles with the function of surface charge transition triggered by pH changes

被引：28

作者：

Zhang, Yan ^{[1
]}

Wang, Chenhong ^{[2
]}

Xu, Chuang ^{[1
]}

Yang, Cuiping ^{[2
]}

Zhang, Zhenqing ^{[2
]}

Yan, Husheng ^{[1
]}

Liu, Keliang ^{[2
]}

机构：

[1] Nankai Univ, Key Lab Funct Polymer Mat, Minist Educ, Inst Polymer Chem, Tianjin 300071, Peoples R China

[2] Beijing Inst Pharmacol & Toxicol, Beijing 100850, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 66期

基金：

中国国家自然科学基金;

关键词：

TUMOR-BEARING MICE; DRUG-DELIVERY; LIPOSOMAL DOXORUBICIN; POLY(ETHYLENE GLYCOL); CELLULAR UPTAKE; NANOPARTICLES; NANOCARRIERS;

D O I：

10.1039/c3cc43334j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Micelles with surface morpholino groups were stealthy at blood and normal tissue pH (7.4) due to the unprotonated hydrophilic morpholino groups on the surfaces. At tumor pH (<7), the micelle surfaces were positively charged because of the protonation of the morpholino groups, which promoted the cellular uptake of the micelles.

引用

页码：7286 / 7288

页数：3

共 12 条

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