ω-Transaminases for the Production of Optically Pure Amines and Unnatural Amino Acids

被引：255

作者：

Mathew, Sam ^{[1
]}

Yun, Hyungdon ^{[1
]}

机构：

[1] Yeungnam Univ, Sch Biotechnol, Gyongsan 712749, Gyeongbuk, South Korea

来源：

ACS CATALYSIS | 2012年 / 2卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

transaminase; biocatalysis; chiral amines; directed evolution; site directed mutagenesis; deracemization; kinetic resolution; asymmetric synthesis; unnatural amino acids; DYNAMIC KINETIC RESOLUTION; ASYMMETRIC-SYNTHESIS; CHIRAL AMINES; DIRECTED EVOLUTION; RATIONAL DESIGN; ALPHA-METHYLBENZYLAMINE; SUBSTRATE-SPECIFICITY; (S)-AMINO ACIDS; AMINOTRANSFERASE; ENZYMES;

D O I：

10.1021/cs300116n

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

omega-Transaminases have been increasingly used as efficient biocatalysts due to their ability to produce a wide range of optically pure amine compounds. Several approaches have been adopted, including screening, engineering, and development of new techniques in reaction systems for different aspects of the enzymes. This review summarizes the various methodologies and approaches adopted to produce enantiomerically pure amines and unnatural amino acids using omega-transaminases.

引用

页码：993 / 1001

页数：9

共 50 条

[1] Substrate profile of an ω-transaminase from Burkholderia vietnamiensis and its potential for the production of optically pure amines and unnatural amino acids
Jiang, Jinju
Chen, Xi
Feng, Jinhui
Wu, Qiaqing
Zhu, Dunming
JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 2014, 100 : 32 - 39
[2] Novel biosynthetic approaches to the production of unnatural amino acids using transaminases
Taylor, PP
Pantaleone, DP
Senkpeil, RF
Fotheringham, IG
TRENDS IN BIOTECHNOLOGY, 1998, 16 (10) : 412 - 418
[3] Unique biocatalytic approach for the synthesis of chirally pure unnatural α- and β-amino acids using novel transaminases
Bhatia, Mohit
Law, Eric
Lewis, Craig
Matcham, George
Nelson, Richard
Rana, Hemlata
Stout, Bhavani
Wang, Alice
PEPTIDE REVOLUTION: GENOMICS, PROTEOMICS & THERAPEUTICS, 2004, : 47 - 48
[4] Unique biocatalytic approach for the synthesis of chirally pure unnatural amino acids using novel transaminases
Lugo, C
Rana, H
Craig, L
Stout, B
Doehner, R
Frances, D
Wu, W
Zhang, YR
Matcham, G
Bhatia, M
BIOPOLYMERS, 2003, 71 (03) : 359 - 359
[5] Optically pure α-amino acids production by the Hydantoinase Process
University of Almeria, Department of Biochemistry and Molecular Biology, CITE I, La Cañada, s/n, 04120 Almeria, Spain
Recent Pat. Biotechnol., 2008, 1 (35-46):
[6] Conversion of Racemic Unnatural Amino Acids to Optically Pure Forms by a Coupled Enzymatic Reaction
Lee, Hannae
Kim, Dongchan
Kim, Sooin
Lee, Hyun Soo
MOLECULES, 2021, 26 (05):
[7] CLINICAL IMPLICATIONS OF UNNATURAL AMINO ACIDS AND AMINES
SJOERDSMA, A
FEDERATION PROCEEDINGS, 1971, 30 (03) : 908 - +
[8] Asymmetric Synthesis of Optically Pure Pharmacologically Relevant Amines Employing ω-Transaminases
Koszelewski, Dominik
Lavandera, Ivan
Clay, Dorina
Rozzell, David
Kroutil, Wolfgang
ADVANCED SYNTHESIS & CATALYSIS, 2008, 350 (17) : 2761 - 2766
[9] Biocatalytic Asymmetric Synthesis of Optically Pure Aromatic Propargylic Amines Employing ω-Transaminases
Schmidt, Nina G.
Simon, Robert C.
Kroutil, Wolfgang
ADVANCED SYNTHESIS & CATALYSIS, 2015, 357 (08) : 1815 - 1821
[10] Production of unnatural amino acids via whole-cell bioconversion with transaminases cloned in E-coli.
Senkpeil, RF
Pantaleone, DP
Fotheringham, IG
Taylor, PP
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1997, 213 : 198 - BIOT

← 1 2 3 4 5 →