Paenibacillin A, a new 2(1H)-pyrazinone ring-containing natural product from the endophytic bacterium Paenibacillus sp Xy-2

被引：8

作者：

Bian, Xiqing ^{[1
,2
]}

Shao, Meili ^{[1
,2
]}

Pan, Huaqi ^{[3
]}

Wang, Kaibo ^{[1
,2
]}

Huang, Shengdong ^{[1
,2
]}

Wu, Xin ^{[4
]}

Xue, Chunmei ^{[1
,2
]}

Hua, Huiming ^{[1
,2
]}

Pei, Yuehu ^{[1
,2
]}

Bai, Jiao ^{[1
,2
]}

机构：

[1] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Peoples R China

[2] Shenyang Pharmaceut Univ, Sch Tradit Chinese Materia Medica, Shenyang 110016, Peoples R China

[3] Chinese Acad Sci, Inst Appl Ecol, Shenyang 110016, Peoples R China

[4] Shenyang Pharmaceut Univ, Sch Life Sci & Biopharmaceut, Shenyang 110016, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2016年 / 30卷 / 02期

关键词：

Paenibacillus sp; endophytic bacterium; secondary metabolites; cytotoxicity; CYCLIC DIPEPTIDES; PATHOGENIC FUNGI; ACID; METABOLITES;

D O I：

10.1080/14786419.2015.1041941

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new 2(1H)-pyrazinone ring-containing natural product, paenibacillin A (1), together with five known diketopiperazine derivatives 2-6 and two known isoflavones 7-8, was isolated from the culture of an endophytic bacterium Paenibacillus sp. Xy-2. The structure of compound 1 was elucidated by extensive spectral methods, including UV, IR, HR-ESI-MS, 1D and 2D NMR and ECD experiments. Compound 1 exhibited moderate cytotoxicity against HL-60 cell line with IC50 value of 50.48M.

引用

页码：125 / 130

页数：6

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