Pharmacokinetics (PK) of Trastuzumab-DM1 (T-DM1) and Paclitaxel (T) in Patients with HER2-Positive Locally Advanced or Metastatic Breast Cancer (MBC) Previously Treated with a Trastuzumab-Containing Regimen

被引：0
|
作者：
Lu, D.
Krop, I.
Modi, S.
Elias, A.
LoRusso, P.
Huang, J.
Lu, M.
Girish, S.
机构：
[1] Genentech Inc, San Francisco, CA 94080 USA
[2] Dana Farber Canc Inst, Boston, MA 02115 USA
[3] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA
[4] Univ Colorado, Sch Med, Aurora, CO USA
[5] Wayne State Univ, Detroit, MI USA
来源：
CANCER RESEARCH | 2010年 / 70卷
关键词：
D O I：
10.1158/0008-5472.SABCS10-P3-14-22
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
P3-14-22
引用
收藏
页数：1
相关论文
共 50 条
  • [1] A Dose-Escalation Study of Trastuzumab-DM1 (T-DM1), Paclitaxel (T), and Pertuzumab (P) in Patients with HER2-Positive, Locally Advanced or Metastatic Breast Cancer (MBC) Previously Treated with a Trastuzumab-Containing Regimen
    Krop, I. E.
    Modi, S.
    Elias, A.
    LoRusso, P.
    Choi, Y. J.
    Lu, M.
    CANCER RESEARCH, 2010, 70
  • [2] Pharmacokinetics (PK) of Trastuzumab Emtansine and Paclitaxel or Docetaxel in Patients with HER2-Positive MBC Previously Treated with a Trastuzumab-Containing Regimen.
    Lu, D.
    Modi, S.
    Elias, A. D.
    Agarwal, P.
    Yi, J-H
    Guardino, A. E.
    Althaus, B. L.
    Girish, S.
    CANCER RESEARCH, 2011, 71
  • [3] A phase Ib/II trial of trastuzumab-DM1 (T-DM1) with pertuzumab (P) for women with HER2-positive, locally advanced or metastatic breast cancer (BC) who were previously treated with trastuzumab (T).
    Miller, K.
    Gianni, L.
    Andre, F.
    Dieras, V.
    Mahtani, R. L.
    Harbeck, N.
    Huang, J. E.
    Shih, T.
    Choi, Y.
    Burris, H. A., III
    JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (15)
  • [4] A PHASE 2 STUDY OF THE HER2 ANTIBODY-DRUG CONJUGATE TRASTUZUMAB-DM1 (T-DM1) IN PATIENTS (PTS) WITH HER2-POSITIVE METASTATIC BREAST CANCER (MBC) PREVIOUSLY TREATED WITH TRASTUZUMAB, LAPATINIB, AND CHEMOTHERAPY
    Krop, I.
    LoRusso, P.
    Miller, K. D.
    Modi, S.
    Yardley, D.
    Rodriguez, G.
    Lu, M.
    Burington, B.
    Agresta, S.
    Rugo, H.
    ANNALS OF ONCOLOGY, 2010, 21 : 97 - 97
  • [5] Trastuzumab emtansine (T-DM1) for HER2-positive advanced breast cancer
    Thibault, C.
    ONCOLOGIE, 2013, 15 (02) : 126 - 127
  • [6] EMILIA: A phase III, randomized, multicenter study of trastuzumab-DM1 (T-DM1) compared with lapatinib (L) plus capecitabine (X) in patients with HER2-positive locally advanced or metastatic breast cancer (MBC) and previously treated with a trastuzumab-based regimen.
    Verma, S.
    Dieras, V.
    Gianni, L.
    Miles, D.
    Welslau, M.
    Pegram, M. D.
    Baselga, J.
    Guardino, E.
    Fang, L.
    Linehan, C. M.
    Blackwell, K. L.
    JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (15)
  • [7] Exposure-safety relationship of trastuzumab emtansine (T-DM1) in patients with HER2-positive locally advanced or metastatic breast cancer (MBC)
    Jin, Jin
    Wang, Bei
    Gao, Yuying
    Samant, Meghan
    Li, Chunze
    Song, Chunyan
    Swain, Sandra M.
    Untch, Michael
    Girish, Sandhya
    JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (15)
  • [8] Results from a phase Ib study of trastuzumab emtansine (T-DM1), paclitaxel (T), and pertuzumab (P) in patients with HER2-positive metastatic breast cancer (MBC) previously treated with trastuzumab.
    Modi, Shanu
    Elias, Anthony D.
    LoRusso, Patricia
    Samant, Meghna
    Guardino, Ellie
    Althaus, Betsy
    Krop, Ian E.
    JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (15)
  • [9] Trastuzumab emtansine (T-DM1) for HER2-positive breast cancer
    Boyraz, Baris
    Sendur, Mehmet A. N.
    Aksoy, Sercan
    Babacan, Taner
    Roach, Emir C.
    Kizilarslanoglu, Muhammet C.
    Petekkaya, Ibrahim
    Altundag, Kadri
    CURRENT MEDICAL RESEARCH AND OPINION, 2013, 29 (04) : 405 - 414
  • [10] Trastuzumab emtansine (T-DM1) in previously treated HER2-positive metastatic breast cancer (MBC): Results from an expanded access study
    Yardley, Denise Aysel
    Krop, Ian E.
    LoRusso, Patricia
    Robert, Nicholas J.
    Mayer, Musa
    Abidoye, Oyewale O.
    Lai, Catherine
    Yoo, Bongin
    Perez, Edith A.
    JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (26)
12345