Protein ROMP: Aqueous Graft-from Ring-Opening Metathesis Polymerization

被引：54
|
作者：
Isarov, Sergey A. [1 ]
Pokorski, Jonathan K. [2 ]
机构：
[1] Case Western Reserve Univ, Sch Med, Dept Physiol & Biophys, Cleveland, OH 44106 USA
[2] Case Western Reserve Univ, Sch Engn, Dept Macromol Sci & Engn, Cleveland, OH 44106 USA
来源：
ACS MACRO LETTERS | 2015年 / 4卷 / 09期
基金：
美国国家科学基金会;
关键词：
TRANSFER RADICAL POLYMERIZATION; IN-SITU GROWTH; CROSS-METATHESIS; CATALYST; TERMINUS;
D O I：
10.1021/acsmacrolett.5b00497
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Ring-opening metathesis polymerization (ROMP) was carried out from the surface of a protein under aqueous conditions. Grubbs' third generation catalyst was modified with PEGylated pyridyl groups to form a water-soluble species that showed high activity in aqueous buffered solutions at near-neutral pH. The modification of a protein with this catalyst to create a stable macroinitiator for ROMP is described. The protein macroinitiator was then used to polymerize water-soluble norbornenes, resulting in high molecular weight protein/polymer conjugates. Varying polymerization time and monomer concentration demonstrated the kinetics of molecular weight evolution and macroinitiator conversion of graft-from ROMP.
引用
收藏
页码：969 / 973
页数：5
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