Concise Stereoselective Total Synthesis of (4R, 6R)-Lactone Moiety Analog of Mevinoline and Compactin

被引：3
|
作者：
Rao, D. Chandra [1 ]
Reddy, D. Kumar [1 ]
Chinnababu, B. [1 ]
Shekhar, V. [1 ]
Venkateswarlu, Y. [1 ]
机构：
[1] Indian Inst Chem Technol, Nat Prod Lab, Nat Prod Chem Div, Hyderabad 500007, Andhra Pradesh, India
来源：
SYNTHETIC COMMUNICATIONS | 2013年 / 43卷 / 22期
关键词：
FeCl3; HMGCo A reductase inhibitor; S-CBS reduction; REDUCTASE INHIBITORS; DERIVATIVES; ML-236B;
D O I：
10.1080/00397911.2012.754470
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple and highly efficient synthetic route has been developed for analogue of HMGCo A reductase inhibitor (1). The strategy utilizes S-Corey-Bakshi-Shibata (CBS) reduction, FeCl3-catalyzed C-H insertion of ethyl diazoacetate. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) for the following free supplemental resource: Full experimental and spectral details.]
引用
收藏
页码：2980 / 2984
页数：5
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