Water-soluble paclitaxel by conjugation to hyperbranched polyglycidols

被引：2
|
作者：
Huang, Xinhua [1 ]
Song, Ga Young [1 ]
Yu, Seong Jae [1 ]
Kim, Il [1 ]
机构：
[1] Pusan Natl Univ, Dept Polymer Sci & Engn, WCU Ctr Synthet Polymer Bioconjugate Hybrid Mat, Pusan 609735, South Korea
来源：
JOURNAL OF MATERIALS SCIENCE | 2013年 / 48卷 / 15期
关键词：
DRUG-DELIVERY; ANTINEOPLASTIC AGENT; BLOCK-COPOLYMER; TAXOL; MICELLES; DESIGN; NANOPARTICLES; DOXORUBICIN; WARFARIN; CARRIERS;
D O I：
10.1007/s10853-013-7302-0
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Chemical conjugates composed of paclitaxel (PTXL) and hyperbranched polyglycidols (HBP) were synthesized using glutaric anhydride as a "bridge" with esterification in dimethylformamide. A series of HBP-PTXL conjugates (HPCs) were synthesized using different molecular weights of HBP and varying ratios of HBP to PTXL, and they were characterized. An intact form of PTXL was regenerated from HPCs under acidic or basic pH conditions. Furthermore, water-soluble HPCs exhibit a more pronounced cytotoxic effect against cancer cells, suggesting that these HPCs can be utilized as tumor-specific therapeutic agents in the form of an injectable drug.
引用
收藏
页码：5163 / 5170
页数：8
相关论文
共 50 条
  • [1] Water-soluble paclitaxel by conjugation to hyperbranched polyglycidols
    Xinhua Huang
    Ga Young Song
    Seong Jae Yu
    Il Kim
    Journal of Materials Science, 2013, 48 : 5163 - 5170
  • [2] Synthesis of Water-soluble Paclitaxel Derivatives
    Li, Qin-Geng (liqingeng@vip.163.com), 1600, Fine Chemicals (34):
  • [3] WATER-SOLUBLE HYPERBRANCHED POLYPHENYLENE - A UNIMOLECULAR MICELLE
    KIM, YH
    WEBSTER, OW
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (11) : 4592 - 4593
  • [4] Synthesis and evaluation of water-soluble paclitaxel prodrugs
    Feng, X
    Yuan, YJ
    Wu, JC
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2002, 12 (22) : 3301 - 3303
  • [5] Water-soluble??????? hyperbranched polymer with high curcumin content
    Nakayama, Yusuke
    Ito, Yutaro
    Fukaminato, Tsuyoshi
    Xu, Wei
    Niidome, Takuro
    Kurihara, Seiji
    Kim, Sunnam
    JOURNAL OF APPLIED POLYMER SCIENCE, 2023, 140 (46)
  • [6] Approaches to water-soluble aliphatic hyperbranched polyamides.
    Feast, WJ
    Aldersley, SJ
    Findlay, P
    Rannard, SP
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2001, 221 : U417 - U417
  • [7] Water-soluble fluorescent hyperbranched polysulfone-amine.
    Gao, C
    Yan, DY
    Zhang, B
    Tang, W
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2001, 222 : U276 - U276
  • [8] Water-soluble hyperbranched polyelectrolytes as scaffolds for molecular assembly
    Bonizzoni, Marco
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2013, 245
  • [9] Synthesis and Property of Water-Soluble Hyperbranched Polyacrylate Emulsion
    Yu Yang
    Xin Xiulan
    Wei Yana
    Liu Hongqin
    Yang Shaoxiang
    ADVANCES IN PRINTING AND PACKAGING TECHNOLOGIES, 2013, 262 : 460 - 463
  • [10] Study of Nitration of Hyperbranched Polyglycidols
    Yu. M. Mikhailov
    L. B. Romanova
    A. V. Darovskikh
    L. S. Barinova
    Russian Journal of Applied Chemistry, 2019, 92 : 445 - 452
12345