Synthesis of fluorine-containing 2-(1-aryl-4-oxo-1,4-dihydrocinnolin-3-yl)-2-oxoacetic acids

被引：0

作者：

Fokin, A. S. ^{[1
]}

Burgart, Ya. V. ^{[1
]}

Saloutin, V. I. ^{[1
]}

Chupakhin, O. N. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Organ Synth, Ural Div, Ekaterinburg 620219, Russia

来源：

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 41卷 / 09期

基金：

俄罗斯基础研究基金会;

关键词：

Hydrolysis; Ethyl; Organic Chemistry; Toluene; Dehydration;

D O I：

10.1007/s11178-005-0349-x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Acid hydrolysis of ethyl 2-(1-aryl-5,6,7,8-tetrafluoro-4-oxo-1,4-dihydrocinnolin-3-yl)-2-oxoacetates gives 2-(1-aryl-5,6,7,8-tetrafluoro-4-oxo-1,4-dihydrocinnolin-3-yl)-2,2-dihydroxyacetic acids which undergo dehydration on heating in toluene to afford 2-(1-aryl-5,6,7,8-tetrafluoro-4-oxo-1,4-dihydrocinnolin-3yl)-2-oxoacetic acids. Reactions of the latter with excess morpholine result in replacement of two fluorine atoms in positions 5 and 7 by the amine residues.

引用

页码：1374 / 1376

页数：3

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