Ruthenium-Catalyzed Straightforward Synthesis of 1,2,3,4-Tetrahydronaphthyridines via Selective Transfer Hydrogenation of Pyridyl Ring with Alcohols

被引：49

作者：

Xiong, Biao ^{[1
]}

Li, Ya ^{[1
]}

Lv, Wan ^{[1
]}

Tan, Zhenda ^{[1
]}

Jiang, Huanfeng ^{[1
]}

Zhang, Min ^{[1
]}

机构：

[1] S China Univ Technol, Sch Chem & Chem Engn, Guangzhou 510641, Peoples R China

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 16期

基金：

中国国家自然科学基金;

关键词：

H BOND FUNCTIONALIZATION; ASYMMETRIC HYDROGENATION; DEHYDROGENATIVE SYNTHESIS; N-ALKYLATION; IONIC LIQUID; AMINES; REDUCTION; COMPLEX; ACID; PHOTOSENSITIZERS;

D O I：

10.1021/acs.orglett.5b01976

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Through a ruthenium-catalyzed selective hydrogen transfer coupling reaction, a novel straightforward synthesis of 1,2,3,4-tetrahydronaphthyridines from o-amino-pyridyl methanols and alcohols has been developed. The synthetic protocol proceeds in an atom- and step-economic fashion together with the advantages of operational simplicity, broad substrate scope, production of water as the only byproduct, and no need for external reducing reagents such as high pressure H-2 gas, offering a highly practical approach for accessing this type of structurally unique products.

引用

页码：4054 / 4057

页数：4

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