A CATALYTIC METHOD FOR THE SYNTHESIS OF 4-ALKYL(ARYL)-6-ARYL-3-CYANO-2(1H)-PYRIDINONES AND THEIR 2-IMINO ISOSTERES AS NONSTEROIDAL CARDIOTONIC AGENTS

被引：0

作者：

Beheshtia, Yahia Sh ^{[1
]}

Khorshidi, Maliheh ^{[1
]}

Heravi, Majid M. ^{[1
]}

Baghernejad, Bita ^{[1
]}

机构：

[1] Alzahra Univ, Sch Sci, Dept Chem, Tehran, Iran

来源：

BULLETIN OF THE CHEMICAL SOCIETY OF ETHIOPIA | 2010年 / 24卷 / 03期

关键词：

3-Cyano-2(1H)-pyridinones; 2-Imino; Cardiotonic; Dimethoxyacetophenone;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly efficient procedure for the synthesis of 4-alkyl(aryl)-6-aryl-3-cyano-2(1H)-pyridinones and their 2-imino isosteres via a one-pot multicomponent reaction of 3,4-dimethoxyacetophenone, malonitrile or ethyl cyanoacetate, an aldehyde and ammonium acetate in the presence of K2CO3 is achieved in good yields.

引用

页码：433 / 438

页数：6

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