No association of paraoxonase genotype or atherosclerosis with cerebral amyloid angiopathy

被引：14

作者：

Yamada, M

Sodeyama, N

Itoh, Y

Otomo, E

Matsushita, M

Mizusawa, H

机构：

[1] Kanazawa Univ, Grad Sch Med Sci, Dept Neurol & Neurobiol Aging, Kanazawa, Ishikawa 920, Japan

[2] Tokyo Inst Psychiat, Dept Neuropathol, Tokyo, Japan

[3] Yokufukai Geriatr Hosp, Dept Pathol, Tokyo, Japan

[4] Yokufukai Geriatr Hosp, Dept Internal Med, Tokyo, Japan

[5] Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept Neurol, Tokyo, Japan

来源：

STROKE | 2002年 / 33卷 / 04期

关键词：

Alzheimer disease; amyloid; atherosclerosis; cerebrovascular disorders; polymorphism (genetics);

D O I：

10.1161/01.STR.0000013673.70986.AB

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and Purpose-Both cerebral amyloid angiopathy (CAA) and paraoxonase have been reported to be related to lipid metabolism and atherosclerosis. We investigated whether the paraoxonase gene (PON1) polymorphism and atherosclerosis are associated with risk of CAA. Methods-Associations of the PON1 polymorphism and atherosclerosis of the aorta and coronary and cerebral arteries with the severity of CAA were investigated in 154 elderly Japanese individuals, including 47 patients with Alzheimer's disease. Results-The PON1 polymorphism or severity of atherosclerosis of the arteries was not associated with the severity of CAA. Conclusions-The PON1 polymorphism and atherosclerosis would not appear to be associated with risk of CAA in the,elderly, although further study with larger samples is necessary for confirmation.

引用

页码：896 / 900

页数：5

共 50 条

[1] The association between cerebral amyloid angiopathy and atherosclerosis in patients with intracerebral hemorrhages
Mendel, Tadeusz Andrzej
Wierzba-Bobrowicz, Teresa
Stepien, Tomasz
Szpak, Grazyna Maria
FOLIA NEUROPATHOLOGICA, 2013, 51 (03) : 243 - 249
[2] Cerebral amyloid angiopathy in traumatic brain injury: association with apolipoprotein E genotype
Leclercq, PD
Murray, LS
Smith, C
Graham, DI
Nicoll, JAR
Gentleman, SM
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2005, 76 (02): : 229 - 233
[3] Cerebral amyloid angiopathy and traumatic brain injury: An association with apolipoprotein E genotype
Leclercq, P
Gentleman, S
Murray, L
Graham, D
Smith, C
Nicoll, J
NEUROBIOLOGY OF AGING, 2002, 23 (01) : S407 - S407
[4] APOLIPOPROTEIN-E GENOTYPE AND CEREBRAL AMYLOID ANGIOPATHY
KALARIA, RN
PREMKUMAR, DRD
LANCET, 1995, 346 (8987): : 1424 - 1424
[5] Association of APOE genotype with CT markers of cerebral amyloid angiopathy in spontaneous intracerebral haemorrhage
Yang, Qiong
Zeng, Xiangzhu
Tang, Lu
Liu, Xiaolu
Xia, Kailin
Gao, Feng
Huang, Xu
Li, Nan
Fan, Dongsheng
STROKE AND VASCULAR NEUROLOGY, 2024,
[6] Cerebral amyloid angiopathy and hemorrhage in traumatic brain injury: Association with APOE genotype.
Nicoll, JA
Leclerq, PD
Murray, LS
Graham, DI
Smith, C
Gentleman, SM
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2002, 61 (05): : 452 - 452
[7] Association of neprilysin polymorphism with cerebral amyloid angiopathy
Yamada, M
Sodeyama, N
Itoh, Y
Takahashi, A
Otomo, E
Matsushita, M
Mizusawa, H
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2003, 74 (06): : 749 - 751
[8] Spatial Association Between Cerebral Microbleeds and β-Amyloid Deposition in Cerebral Amyloid Angiopathy
Dierksen, Gregory A.
Skehan, Maureen E.
Khan, Muhammad A.
Becker, John A.
Betensky, Rebecca A.
Frosch, Matthew P.
Rosand, Jonathan
Viswanathan, Anand
Johnson, Keith
Salat, David H.
Greenberg, Steven M.
STROKE, 2010, 41 (04) : E342 - E342
[9] Influence of apolipoprotein E genotype on cerebral amyloid angiopathy in the elderly
Itoh, Y
Yamada, M
Suematsu, N
Matsushita, M
Otomo, E
STROKE, 1996, 27 (02) : 216 - 218
[10] The association between hypertensive angiopathy and cerebral amyloid angiopathy in primary intracerebral hemorrhage
Zhu, Yuyi
Liu, Lu
Zhong, Luyao
Cheng, Yajun
Zhang, Shihong
Wu, Bo
Wang, Deren
Xu, Mangmang
FRONTIERS IN NEUROLOGY, 2023, 14

← 1 2 3 4 5 →