Biochemical Recurrence of Prostate Cancer: Initial Results with [18F]PSMA-1007 PET/CT

被引：49
|
作者：
Giesel, Frederik L. [1 ,2 ,3 ]
Will, Leon [1 ]
Kesch, Claudia [4 ]
Freitag, Martin [2 ,5 ]
Kremer, Christophe [1 ]
Merkle, Jonas [1 ]
Neels, Oliver C. [6 ]
Cardinale, Jens [6 ]
Hadaschik, Boris [4 ]
Hohenfellner, Markus [4 ]
Kopka, Klaus [6 ]
Haberkorn, Uwe [1 ,2 ]
Kratochwil, Clemens [1 ]
机构：
[1] Univ Hosp Heidelberg, Dept Nucl Med, D-69120 Heidelberg, Germany
[2] German Canc Res Ctr, Cooperat Unit Nucl Med, Heidelberg, Germany
[3] German Canc Consortium DKTK, Heidelberg, Germany
[4] Univ Hosp Heidelberg, Dept Urol, Heidelberg, Germany
[5] German Canc Res Ctr, Dept Radiol, Heidelberg, Germany
[6] German Canc Res Ctr, Div Radiopharmaceut Chem, Heidelberg, Germany
来源：
JOURNAL OF NUCLEAR MEDICINE | 2018年 / 59卷 / 04期
关键词：
peptides; PET/CT; biochemical recurrence; F-18-PSMA-1007; PSMA-PET; prostate cancer; POSITRON-EMISSION-TOMOGRAPHY; GA-68-LABELED PSMA LIGAND; RADICAL PROSTATECTOMY; RADIATION-DOSIMETRY; MEMBRANE ANTIGEN; BIODISTRIBUTION; DIAGNOSIS; PET/MRI;
D O I：
10.2967/jnumed.117.196329
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Biochemical recurrence (BCR) is a concern for prostate cancer patients after local treatment. Ga-68-labeled prostate-specific membrane antigen (PSMA) ligands have significantly improved prostate cancer imaging. However, several F-18-labeled ligands that were developed as fluorinated tracers might present advantages. In this study, we analyzed the potential of F-18-PSMA-1007 in patients with BCR. Methods: Twelve patients with BCR after local treatment underwent PET/CT scans 1 and 3 h after injection of F-18-PSMA-1007. Results: F-18-PSMA-1007 PET/CT detected lesions in 9 of 12 patients (75%). A significant difference was observed when comparing the tracer uptake in F-18-PSMA-1007-positive lesions 1 and 3 h after injection (median SUVmax, 7.00 vs. 11.34; P < 0.001; n = 76). Forty-four (88%) of 50 F-18-PSMA-1007-positive lymph nodes had a short-axis diameter of less than 8 mm. Conclusion: In this pilot study, F-18-PSMA-1007 PET/CT presented high potential for localization of recurrent disease in prostate cancer patients with BCR.
引用
收藏
页码：632 / 635
页数：4
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