Variation of BMP3 Contributes to Dog Breed Skull Diversity

被引:126
|
作者
Schoenebeck, Jeffrey J. [1 ]
Hutchinson, Sarah A. [2 ]
Byers, Alexandra [1 ]
Beale, Holly C. [1 ]
Carrington, Blake
Faden, Daniel L. [1 ]
Rimbault, Maud [1 ]
Decker, Brennan [1 ]
Kidd, Jeffrey M. [3 ]
Sood, Raman
Boyko, Adam R. [4 ]
Fondon, John W., III [5 ]
Wayne, Robert K. [6 ]
Bustamante, Carlos D. [3 ]
Ciruna, Brian [2 ,7 ]
Ostrander, Elaine A. [1 ]
机构
[1] NHGRI, Canc Genet Branch, Bethesda, MD 20892 USA
[2] Hosp Sick Children, Program Dev & Stem Cell Biol, Toronto, ON M5G 1X8, Canada
[3] Stanford Sch Med, Dept Genet, Stanford, CA USA
[4] Cornell Univ, Coll Vet Med, Dept Biomed Sci, Ithaca, NY 14853 USA
[5] Univ Texas Arlington, Dept Biol, Arlington, TX 76019 USA
[6] Univ Calif Los Angeles, Dept Ecol & Evolutionary Biol, Los Angeles, CA USA
[7] Univ Toronto, Dept Mol Genet, Toronto, ON, Canada
来源
PLOS GENETICS | 2012年 / 8卷 / 08期
基金
英国生物技术与生命科学研究理事会; 美国国家科学基金会; 加拿大自然科学与工程研究理事会;
关键词
CHROMOSOME ASSIGNMENT; GENETIC-ANALYSIS; SELECTIVE SWEEP; ZEBRAFISH; ASSOCIATION; EXPRESSION; SEQUENCE;
D O I
10.1371/journal.pgen.1002849
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Since the beginnings of domestication, the craniofacial architecture of the domestic dog has morphed and radiated to human whims. By beginning to define the genetic underpinnings of breed skull shapes, we can elucidate mechanisms of morphological diversification while presenting a framework for understanding human cephalic disorders. Using intrabreed association mapping with museum specimen measurements, we show that skull shape is regulated by at least five quantitative trait loci (QTLs). Our detailed analysis using whole-genome sequencing uncovers a missense mutation in BMP3. Validation studies in zebrafish show that Bmp3 function in cranial development is ancient. Our study reveals the causal variant for a canine QTL contributing to a major morphologic trait.
引用
收藏
页数:11
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