Non-motor symptoms of Parkinson's disease: diagnosis and management

被引:1942
|
作者
Chaudhuri, KR
Healy, DG
Schapira, AHV
机构
[1] Kings Coll Hosp London, Guys Kings & St Thomas Sch Med, Movement Disorders Unit, London SE5 9RS, England
[2] Univ Hosp Lewisham, London, England
[3] UCL, Royal Free Hosp, Sch Med, London, England
来源
LANCET NEUROLOGY | 2006年 / 5卷 / 03期
关键词
D O I
10.1016/S1474-4422(06)70373-8
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The clinical diagnosis of Parkinson's disease rests on the identification of the characteristics related to dopamine deficiency that are a consequence of degeneration of the substantia nigra pars compacta. However, nondopaminergic and non-motor symptoms are sometimes present before diagnosis and almost inevitably emerge with disease progression. Indeed, non-motor symptoms dominate the clinical picture of advanced Parkinson's disease and contribute to severe disability, impaired quality of life, and shortened life expectancy. By contrast with the dopaminergic symptoms of the disease, for which treatment is available, non-motor symptoms are often poorly recognised and inadequately treated. However, attention is now being focused on the recognition and quantitation of non-motor symptoms, which will form the basis of improved treatments. Some non-motor symptoms, including depression, constipation, pain, genitourinary problems, and sleep disorders, can be improved with available treatments. Other non-motor symptoms can be more refractory and need the introduction of novel non-dopaminergic drugs. Inevitably, the development of treatments that can slow or prevent the progression of Parkinson's disease and its multicentric neurodegeneration provides the best hope of curing non-motor symptoms.
引用
收藏
页码:235 / 245
页数:11
相关论文
共 50 条
  • [1] Management of Motor and Non-Motor Symptoms in Parkinson’s Disease
    Fabienne Sprenger
    Werner Poewe
    CNS Drugs, 2013, 27 : 259 - 272
  • [2] Management of Motor and Non-Motor Symptoms in Parkinson's Disease
    Sprenger, Fabienne
    Poewe, Werner
    CNS DRUGS, 2013, 27 (04) : 259 - 272
  • [3] Ladasten in the management of non-motor symptoms of Parkinson's disease
    Sarycheva, T. N.
    Rybak, V. A.
    Kurushina, O. V.
    ZHURNAL NEVROLOGII I PSIKHIATRII IMENI S S KORSAKOVA, 2011, 111 (01) : 85 - 87
  • [4] Non-motor symptoms and Parkinson's disease
    Lessig, Stephanie
    Song, David
    Tecoma, Evelyn
    Corey-Bloom, Jody
    NEUROLOGY, 2007, 68 (12) : A36 - A36
  • [5] Non-motor symptoms in Parkinson's disease
    Elfekih, M.
    Bedoui, I.
    Douma, B.
    Mansour, M.
    Derbali, H.
    Riahi, A.
    Meselmani, M.
    Zaouali, J.
    Mrissa, R.
    MOVEMENT DISORDERS, 2021, 36 : S170 - S170
  • [6] Non-motor symptoms in Parkinson's disease
    Borgohain, R.
    Venigalla, N. K.
    Mridula, R.
    Jabeen, S. A.
    Kanikannan, M. A.
    MOVEMENT DISORDERS, 2009, 24 : S523 - S523
  • [7] The non-motor symptoms in Parkinson's disease
    Mihancea, P.
    Brisc, C. M.
    Havasi, N.
    Brisc, C.
    EUROPEAN JOURNAL OF NEUROLOGY, 2008, 15 : 122 - 122
  • [8] Non-motor symptoms of Parkinson's disease
    Deuschl, G
    AKTUELLE NEUROLOGIE, 2003, 30 : S242 - S245
  • [9] Non-motor symptoms of Parkinson's disease
    Carroll, Vincent
    Rossiter, Rachel
    Blanchard, Denise
    AUSTRALIAN JOURNAL OF GENERAL PRACTICE, 2021, 50 (11) : 812 - 817
  • [10] Non-motor symptoms of Parkinson's disease
    Hou, Jyh-Gong Gabriel
    Lai, Eugene C.
    INTERNATIONAL JOURNAL OF GERONTOLOGY, 2007, 1 (02) : 53 - 64