Short course of radiation therapy in elderly patients with glioblastoma multiforme

被引：23
|
作者：
Idbaih, A. [1 ,2 ]
Taillibert, S. [1 ,2 ]
Simon, J. -M. [1 ]
Psimaras, D. [2 ]
Schneble, H. -M. [3 ]
Lopez, S. [1 ]
Lang, P. [1 ]
Toubiana, T. [1 ]
Feuvret, L. [1 ]
Delattre, J. -Y. [2 ]
Mazeron, J. -J. [1 ]
机构：
[1] Grp Hosp Pitie Salpetriere, AP HP, Serv Radiotherapie Oncol, F-75651 Paris 13, France
[2] Grp Hosp Pitie Salpetriere, AP HP, Serv Neurol Mazarin, F-75651 Paris 13, France
[3] Grp Hosp Lariboisiere, AP HP, Serv Neurol, Paris, France
来源：
CANCER RADIOTHERAPIE | 2008年 / 12卷 / 08期
关键词：
Elderly; Glioblastoma multiforme; Glioma; Karnofsky performance status; Radiotherapy;
D O I：
10.1016/j.canrad.2008.05.007
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Purpose. - The optimal schedule of irradiation in elderly patients suffering from glioblastoma multiforme (GBM) is unsettled. Materials and methods. - This study reviewed the charts of 28 consecutive GBM patients aged 70 years or more with a Karnofsky Performance Status (KPS) greater than or equal to 70 who received a short course of radiotherapy (40 grays in 15 fractions over three weeks). Results. - The median age at surgery was 74.6 years (range, 70.1-85.7). No patient received prior or concomitant chemotherapy. The median progression-free survival and overall survival were 21.6 weeks (95% Cl, 17.0-39.9) and 50.6 weeks (95% Cl, 26.3-62.0), respectively. Even within a narrow range (<90 or >= 90), KPS remained a prognostic factor (p=0.03). Tolerance appeared acceptable in terms of KPS changes and corticosteroid use during radiation therapy. Conclusion. - These results support the efficacy of short schedule radiotherapy for GBM in elderly patients with a good KPS. (C) 2008 Published by Elsevier Masson SAS.
引用
收藏
页码：788 / 792
页数：5
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