Serologic Markers for Ebolavirus Among Healthcare Workers in the Democratic Republic of the Congo

被引：9

作者：

Hoff, Nicole A. ^{[1
]}

Mukadi, Patrick ^{[2
,3
]}

Doshi, Reena H. ^{[1
]}

Bramble, Matthew S. ^{[4
]}

Lu, Kai ^{[5
,6
]}

Gadoth, Adva ^{[1
]}

Sinai, Cyrus ^{[1
]}

Spencer, D'Andre ^{[1
]}

Nicholson, Bradley P. ^{[7
]}

Williams, Russell ^{[8
]}

Mossoko, Matthias ^{[9
]}

Ilunga-Kebela, Benoit ^{[9
]}

Wasiswa, Joseph ^{[8
,9
]}

Okitolonda-Wemakoy, Emile ^{[10
]}

Alfonso, Vivian H. ^{[1
]}

Steffen, Imke ^{[5
,6
]}

Muyembe-Tamfum, Jean-Jacques ^{[2
,3
]}

Simmons, Graham ^{[5
,6
]}

Rimoin, Anne W. ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Fielding Sch Publ Hlth, Dept Epidemiol, 650 Charles E Young Dr South,CHS St 41-275, Los Angeles, CA 90095 USA

[2] Univ Kinshasa, Inst Natl Rech Biomed, Kinshasa, DEM REP CONGO

[3] Univ Kinshasa, Fac Med, Kinshasa, DEM REP CONGO

[4] Childrens Natl Med Ctr, Childrens Res Inst, Dept Genet Med Res, Washington, DC 20010 USA

[5] Blood Syst Res Inst, San Francisco, CA USA

[6] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA

[7] Vet Affairs Med Ctr, Mol Epidemiol Res Lab, Durham, NC USA

[8] Univ Calif Los Angeles, DRC Res Program, Los Angeles, CA USA

[9] Minist Sante Publ, Direct Lutte Maladie, Kinshasa, DEM REP CONGO

[10] Univ Kinshasa, Ecole Sante Publ, Kinshasa, DEM REP CONGO

来源：

JOURNAL OF INFECTIOUS DISEASES | 2019年 / 219卷 / 04期

基金：

比尔及梅琳达.盖茨基金会;

关键词：

Ebola virus; serology; Democratic Republic of the Congo; healthcare workers; VIRUS DISEASE; IGG ANTIBODIES; SIERRA-LEONE; HEMORRHAGIC-FEVER; TRANSMISSION; OUTBREAK; RISK; PREVALENCE; EPIDEMIOLOGY; TUBERCULOSIS;

D O I：

10.1093/infdis/jiy499

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Healthcare settings have played a major role in propagation of Ebola virus (EBOV) outbreaks. Healthcare workers (HCWs) have elevated risk of contact with EBOV-infected patients, particularly if safety precautions are not rigorously practiced. We conducted a serosurvey to determine seroprevalence against multiple EBOV antigens among HCWs of Boende Health Zone, Democratic Republic of the Congo, the site of a 2014 EBOV outbreak. Interviews and specimens were collected from 565 consenting HCWs. Overall, 234 (41.4%) of enrolled HCWs were reactive to at least 1 EBOV protein: 159 (28.1%) were seroreactive for anti-glycoprotein immunoglobulin G (IgG), 89 (15.8%) were seroreactive for anti-nucleoprotein IgG, and 54 (9.5%) were VP40 positive. Additionally, sera from 16 (2.8%) HCWs demonstrated neutralization capacity. These data demonstrate that a significant proportion of HCWs have the ability to neutralize virus, despite never having developed Ebola virus disease symptoms, highlighting an important and poorly documented aspect of EBOV infection and progression.

引用

页码：517 / 525

页数：9

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