Synthesis and Antibacterial Activity of Oxazolidinone Derivatives Containing Nitro Heteroaromatic Moiety

被引：14
|
作者：
Xu Boxuan [1 ]
Ding Xiudong [2 ]
Wu Yachuang [1 ]
Cui Lei [2 ]
Qian Ping [1 ]
Wang Di [2 ]
Zhao Yanfang [1 ]
机构：
[1] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China
[2] 309th Hosp PLA, Dept Clin Lab, Beijing 100091, Peoples R China
来源：
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES | 2018年 / 34卷 / 01期
关键词：
Oxazolidinone derivative; Antibacterial activity; Linezolid; Ranbezolid; AGENTS; DISCOVERY; SAR;
D O I：
10.1007/s40242-018-7302-3
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of novel oxazolidinone derivatives containing nitro heteroaromatic moiety was synthesized and characterized by means of H-1 NMR and MS spectra. All target compounds were evaluated for their in vitro antibacterial activities against S.au 29213, methicillin-resistant Staphylococcus aureus(MRSA) and vancomycin-resistant Enterococcus(VRE) by minimum inhibitory concentration(MIC) assay. Most of them exhibited antibacterial activity against S. au 29213, MRSA and VRE. Among them, compounds 10e and 10f displayed better activity than the control.
引用
收藏
页码：51 / 56
页数：6
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