Lysosome Enlargement Enhanced Photochemotherapy Using a Multifunctional Nanogel

Large lysosomes are susceptible toward rupture because of an increased membrane tension. Here we report a strategy to first enlarge and weaken the lysosome and then destroy it to boost the efficiency of photochethotherapy using a :hyaluronan nanogel, tarrying chloroquine as a lysosomal expander; rhodamine B as a photosensitive lysosomal destroyer, and cisplatin as a chemotherapeutic. This all-in-one nanogel provides la facile approach and new insight into improve the photochemotherapy, by making use of lysosome's size, as a risk factor in lysosomal destabilization.