Epithelial morphogenesis in the perinatal mouse uterus

被引:8
|
作者
Vue, Zer [1 ,2 ]
Behringer, Richard R. [1 ,2 ]
机构
[1] Baylor Coll Med, Program Dev Biol, Houston, TX 77030 USA
[2] Univ Texas MD Anderson Canc Ctr, Dept Genet, Houston, TX 77030 USA
关键词
adenogenesis; female reproductive tract; postnatal development; UTERINE GLANDS; EMBRYO;
D O I
10.1002/dvdy.234
中图分类号
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号
100101 ;
摘要
Background The uterus is the location where multiple events occur that are required for the start of new life in mammals. The adult uterus contains endometrial or uterine glands that are essential for female fertility. In the mouse, uterine glands are located in the lateral and antimesometrial regions of the uterine horn. Previous three-dimensional (3D)-imaging of the adult uterus, its glands, and implanting embryos has been performed by multiple groups, using fluorescent microscopy. Adenogenesis, the formation of uterine glands, initiates after birth. Recently, we created a 3D-staging system of mouse uterine gland development at postnatal time points, using light sheet fluorescent microscopy. Here, using a similar approach, we examine the morphological changes in the epithelium of the perinatal mouse uterus. Results The uterine epithelium exhibits dorsoventral (mesometrial-antimesometrial) patterning as early as 3 days after birth (P3), marked by the presence of the dorsally positioned developing uterine rail. Uterine gland buds are present beginning at P4. Novel morphological epithelial structures, including a ventral ridge and uterine segments were identified. Conclusions The perinatal mouse uterine luminal epithelium develops dorsal-ventral morphologies at 3 to 4 days postpartum. Between 5 and 6 days postpartum uterine epithelial folds form, defining alternating left-right segments.
引用
收藏
页码:1377 / 1386
页数:10
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