Carvedilol-loaded polyvinylpyrrolidone electrospun nanofiber film for sublingual delivery

The study aimed to prepare and evaluate carvedilol loaded polyvinylpyrrolidone (PVP) and polyethylene glycol 400 (PEG 400) electrospun nanofibers for sublingual drug delivery. The fabricated formulation was character-ized using scanning electron microscopy, Fourier transform infrared spectroscopy (FT-IR) and molecular docking techniques. Prepared nanofibers film was analyzed in terms of surface morphology, thickness, folding en-durance, and drug release profile. The results indicated that carvedilol was amorphous in the fibers form and an average diameter of 745 +/- 57 nm with a smooth cylinder cross-link structure. Both FT-IR and molecular docking studies demonstrated that hydrogen bonding contributed to drug-polymer intermolecular interaction. The drug dissolution and permeation were much higher than those of the physical mixture. Overall the devel-oped fast dissolving electrospun polymeric film is a promising delivery carrier for carvedilol sublingual delivery.