Osteosarcoma (OS), a highly aggressive bone tumor, mainly occurs in young patients and always presents abnormalities in molecular biology, such as microRNAs (miRNAs). However, the characteristic and underlying mechanism of miR-671-5p in OS are still unclear. In this study, we certify that miR-671-5p is remarkably downregulated in OS tissues and cells. Overexpressed miR-671-5p can suppress OS cell proliferation in vivo and in vitro, by the way of arresting cell-cycle progression. The overexpression of cyclin D1 (CCND1) and CDC34 promotes cell proliferation and cell-cycle promotion, whose functions are contrary to miR-671-5p. miR-671-5p directly binds to CCND1 and CDC34, which are thought as the key factors in regulating cell cycle. Taken together, our results suggest that by targeting CCND1 and CDC34, miR-671-5p plays a tumor suppressor in OS to inhibit the development of OS, implicating it as a novel target for therapeutic intervention in OS.
机构:
Dalian Med Univ, Dalian 116044, Peoples R China
Dalian Municipal Cent Hosp, Dept Spinal Surg, Dalian 116033, Peoples R ChinaDalian Med Univ, Dalian 116044, Peoples R China
Xu, Lichen
Zhang, Pan
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China Med Univ, Peoples Hosp, Peoples Hosp Liaoning Prov, Dept Orthopaed, Shenyang 110016, Peoples R ChinaDalian Med Univ, Dalian 116044, Peoples R China
Zhang, Pan
Zhang, Guiqi
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Dalian Municipal Cent Hosp, Dept Spinal Surg, Dalian 116033, Peoples R ChinaDalian Med Univ, Dalian 116044, Peoples R China
Zhang, Guiqi
Shen, Zhaoliang
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Jinzhou Med Univ, Affiliated Hosp 3, Dept Orthoped, Jinzhou 121000, Peoples R ChinaDalian Med Univ, Dalian 116044, Peoples R China
Shen, Zhaoliang
Bai, Xizhuang
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Dalian Med Univ, Dalian 116044, Peoples R China
China Med Univ, Peoples Hosp, Peoples Hosp Liaoning Prov, Dept Orthopaed, Shenyang 110016, Peoples R ChinaDalian Med Univ, Dalian 116044, Peoples R China