NO inhibitory guaianolide-derived terpenoids from Artemisia argyi

被引：65
|
作者：
Wang, Shu [1 ]
Li, Jun [2 ]
Sun, Jian [1 ]
Zeng, Ke-wu [1 ]
Cui, Jing-rong [1 ]
Jiang, Yong [1 ]
Tu, Peng-fei [1 ]
机构：
[1] Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
[2] Beijing Univ Chinese Med, Modern Res Ctr Tradit Chinese Med, Beijing 100029, Peoples R China
来源：
FITOTERAPIA | 2013年 / 85卷
基金：
中国国家自然科学基金;
关键词：
Artemisia argyi; Guaianolide-derived terpenoid; Absolute configuration; Nitric oxide; FARNESYL-PROTEIN TRANSFERASE; SESQUITERPENE LACTONES; NITRIC-OXIDE; DIMERIC GUAIANOLIDES; CIRCULAR-DICHROISM; ANTITUMOR-ACTIVITY; CONSTITUENTS; CHEMOSENSITIVITY; ARTEMINOLIDE; INFLAMMATION;
D O I：
10.1016/j.fitote.2012.12.005
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
An unusual dimeric guaianolide, artemilinin A (1) and a sesquiterpene-monoterpene lactone, isoartemisolide (2), were isolated from the leaves of Artemisia argyi. Their structures were elucidated on the basis of extensive spectroscopic analysis (IR, HR-ES1MS, 1D- and 2D-NMR), and the absolute configurations were determined by CD spectra and quantum chemical ECD calculation. Furthermore, in in vitro assay, compound 2 exhibited pronounced inhibition on the lipopolysaccharide (LPS)-induced nitric oxide (NO) production in BV-2 microglial cells with an IC50 value of 4.00 mu M. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码：169 / 175
页数：7
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