Mechanism of anticancer activity of buforin IIb, a histone H2A-derived peptide

被引：146

作者：

Lee, Hyun Soo ^{[2
]}

Park, Chan Bae ^{[2
]}

Kim, Jung Min ^{[2
]}

Jang, Su A. ^{[2
]}

Park, In Yup ^{[2
]}

Kim, Mi Sun ^{[3
]}

Cho, Ju Hyun ^{[1
]}

Kim, Sun Chang ^{[2
]}

机构：

[1] Gyeongsang Natl Univ, Life Sci Res Inst, Dept Biol, Jinju 660701, South Korea

[2] Korea Adv Inst Sci & Technol, Dept Biol Sci, Taejon 305701, South Korea

[3] Korea Atom Energy Res Inst, Biomass Team, Taejon 305343, South Korea

来源：

CANCER LETTERS | 2008年 / 271卷 / 01期

关键词：

Anticancer peptide; Buforin IIb; Ganglioside; Histone H2A;

D O I：

10.1016/j.canlet.2008.05.041

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Buforin IIb is a novel cell-penetrating anticancer peptide derived from histone H2A. Here we analyzed the anticancer activity and cancer cell-killing mechanism of buforin IIb. Buforin IIb displayed selective cytotoxicity against 62 cancer cell lines by specifically targeting cancer cells through interaction with cell surface gangliosides. It traversed cancer cell membranes without damaging them and accumulated primarily in the nuclei. Once inside the cells, buforin IIb induced mitochondria-dependent apoptosis. In vivo analysis revealed that buforin IIb displayed significant tumor suppression activity in mice with tumor xenograft. Overall, these results suggest that buforin IIb constitutes a novel therapeutic agent for the treatment of cancers. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：47 / 55

页数：9

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