Synthesis, spectroscopic and biological studies of diorganotin(IV) and triorganotin(IV) derivatives of albendazole, ofloxacin and 3-carboxypropyldisulfide

Diorganotin(IV) and triorganotin(IV) derivatives of the types R(2)SnA (R=n-Bu and n-octyl) and (R3Sn)(2)A (R = n-Bu), where A is the anion of albendazole {methyl[(5-propylsulfanyl-3H-benzoimidazol-2-yl)amino]formate}, ofloxacin {(RS)-7-fluoro-2-methyl-6-(4methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclo[7.3.1.0(5,13)] trideca-5(13),6,8,11-tetraene-11-carboxylicacid} and 3-carboxypropyldisulfide, have been synthesized. The complexes 1-9 obtained were characterized by elemental analysis as well as infrared (Fourier transform infrared), nuclear magnetic resonance (H-1, C-13 and Sn-119 NMR) and ultraviolet spectroscopy. On the basis of these spectroscopic studies it was proposed that diorganotin complexes of 3-carboxypropyldisulfide having 1: 1 stoichiometry and complexes of albendazole and ofloxacin having 1: 2 stoichiometry show tetrahedral geometry around the tin atom with monodentate behavior of the carboxylate group in ofloxacin and 3-carboxypropyldisulfide. Triorganotin complexes of 3-carboxypropyldisulfide having 1: 1 stoichiometry and complexes of ofloxacin and albendazole having 1: 2 stoichiometry show trigonal bipyramidal geometry. The ligand molecule is bound to the Sn atom through carboxyl oxygen atoms in ofloxacin and 3-carboxypropyldisulfide, and to the nitrogen atom in albendazole. The biological activity of the synthesized complexes 4, 5 and 6 has been screened against Candida albicans