Development of NIR Fluorescent Dyes Based on Si-rhodamine for in Vivo Imaging

被引：254

作者：

Koide, Yuichiro ^{[1
,3
]}

Urano, Yasuteru

Hanaoka, Kenjiro ^{[1
,3
]}

Piao, Wen ^{[1
,3
]}

Kusakabe, Moriaki ^{[4
]}

Saito, Nae ^{[2
]}

Terai, Takuya ^{[1
,3
]}

Okabe, Takayoshi ^{[2
]}

Nagano, Tetsuo ^{[1
,3
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

[2] Univ Tokyo, Open Innovat Ctr Drug Discovery, Bunkyo Ku, Tokyo 1130033, Japan

[3] Japan Sci & Technol Agcy, JST, CREST, Chiyoda Ku, Tokyo 1020075, Japan

[4] Matrix Cell Res Inst Inc, Ushi Ku, Ibaraki 3001232, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2012年 / 134卷 / 11期

关键词：

CANCER; MOUSE;

D O I：

10.1021/ja210375e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We have developed a series of novel near-infrared (NIR) wavelength-excitable fluorescent dyes, SiR-NIRs, by modifying the Si-rhodamine scaffold to obtain emission in the range suitable for in vivo imaging. Among them, SiR680 and SiR700 showed sufficiently high quantum efficiency in aqueous media. Both antibody-bound and free dye exhibited high tolerance to photobleaching in aqueous solution. Subcutaneous xenograft tumors were successfully visualized in a mouse tumor model using SiR700-labeled anti-tenascin-C (TN-C) antibody, SiR700-RCB1. SiR-NIRs are expected to be useful as labeling agents for in vivo imaging studies including multicolor imaging, and also as scaffolds for NW fluorescence probes.

引用

页码：5029 / 5031

页数：3

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