Single nucleotide polymorphisms typing of Mycobacterium leprae reveals focal transmission of leprosy in high endemic regions of India

被引：15
|
作者：
Lavania, M. [1 ]
Jadhav, R. S. [2 ]
Turankar, R. P. [1 ]
Chaitanya, V. S. [1 ]
Singh, M. [3 ]
Sengupta, U. [1 ]
机构：
[1] TLM Community Hosp, Stanley Browne Lab, Delhi 110093, India
[2] Govt Inst Sci, Dept Microbiol, Bombay, Maharashtra, India
[3] LRS Inst TB & Resp Dis, Delhi, India
来源：
CLINICAL MICROBIOLOGY AND INFECTION | 2013年 / 19卷 / 11期
关键词：
Delhi; Mycobacterium leprae; Purulia; single-nucleotide polymorphisms; transmission; SHORT TANDEM REPEATS; STRAINS; POPULATION; DIVERSITY;
D O I：
10.1111/1469-0691.12125
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Earlier studies indicate that genotyping of Mycobaterium leprae based on single-nucleotide polymorphisms (SNPs) is useful for analysis of the global spread of leprosy. In the present study, we investigated the diversity of M.leprae at eight SNP loci using 180 clinical isolates obtained from patients with leprosy residing mainly in Delhi and Purulia (West Bengal) regions. It was observed that the frequency of SNP type 1 and subtype D was most predominant in the Indian population. Further, the SNP type 2 subtype E was noted only from East Delhi region and SNP type 2 subtype G was noted only from the nearby areas of Hoogly district of West Bengal. These results indicate the occurrence of focal transmission of M.leprae infection and demonstrate that analysis by SNP typing has great potential to help researchers in understanding the transmission of M.leprae infection in the community.
引用
收藏
页码：1058 / 1062
页数：5
相关论文
共 47 条
  • [1] Single Nucleotide Polymorphism Typing of Mycobacterium ulcerans Reveals Focal Transmission of Buruli Ulcer in a Highly Endemic Region of Ghana
    Roeltgen, Katharina
    Qi, Weihong
    Ruf, Marie-Therese
    Mensah-Quainoo, Ernestina
    Pidot, Sacha J.
    Seemann, Torsten
    Stinear, Timothy P.
    Kaeser, Michael
    Yeboah-Manu, Dorothy
    Pluschke, Gerd
    PLOS NEGLECTED TROPICAL DISEASES, 2010, 4 (07):
  • [2] Association of non-tuberculous mycobacteria with Mycobacterium leprae in environment of leprosy endemic regions in India
    Turankar, Ravindra P.
    Singh, Vikram
    Gupta, Hariom
    Pathak, Vinay Kumar
    Ahuja, Madhvi
    Singh, Itu
    Lavania, Mallika
    Dinda, Amit K.
    Sengupta, Utpal
    INFECTION GENETICS AND EVOLUTION, 2019, 72 : 191 - 198
  • [3] Genotyping of Mycobacterium leprae strains from a region of high endemic leprosy prevalence in India
    Lavania, Mallika
    Jadhav, Rupendra
    Turankar, Ravindra P.
    Singh, Itu
    Nigam, Astha
    Sengupta, U.
    INFECTION GENETICS AND EVOLUTION, 2015, 36 : 256 - 261
  • [4] Genotyping of Mycobacterium leprae for understanding the distribution and transmission of leprosy in endemic provinces of China
    Chokkakula, Santosh
    Shui, Tiejun
    Jiang, Haiqin
    Yang, Jun
    Li, Xiong
    He, Jun
    Shen, Limei
    Liu, Jie
    Wang, De
    Suryadevara, Naveen Chandra
    Pathakumari, Balaji
    Wang, Le
    Chen, Yanqing
    Shi, Ying
    Zhang, Wenyue
    Wang, Hao
    Chen, Huan
    Kuang, Yanfei
    Li, Bin
    Yua, Meiwen
    Yan, Liangbin
    Vissa, Varalakshmi
    Tsang, Lemuel Shui Lun
    Li, Jinlan
    Wang, Hongsheng
    INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2020, 98 : 6 - 13
  • [5] Seroreactivity to new Mycobacterium leprae protein antigens in different leprosy-endemic regions in Brazil
    Hungria, Emerith Mayra
    de Oliveira, Regiane Morillas
    Osorio Maroclo de Souza, Ana Lucia
    Costa, Mauricio Barcelos
    Brito de Souza, Vania Nieto
    Silva, Eliane Aparecida
    Vilani Moreno, Fatima Regina
    Salles Nogueira, Maria Esther
    Sales Nogueira Costa, Maria Renata
    Uso Ruiz Silva, Sonia Maria
    Buehrer-Sekula, Samira
    Reed, Steven G.
    Duthie, Malcolm S.
    de Araujo Stefani, Mariane Martins
    MEMORIAS DO INSTITUTO OSWALDO CRUZ, 2012, 107 : 104 - 111
  • [6] Single nucleotide polymorphism-based molecular typing of M. leprae from multicase families of leprosy patients and their surroundings to understand the transmission of leprosy
    Turankar, R. P.
    Lavania, M.
    Chaitanya, V. S.
    Sengupta, U.
    Darlong, J.
    Darlong, F.
    Sai, K. S. R. Siva
    Jadhav, R. S.
    CLINICAL MICROBIOLOGY AND INFECTION, 2014, 20 (03) : O142 - O149
  • [7] Detection of Mycobacterium leprae infection in family clusters from six leprosy-endemic regions in Colombia
    Serrano-Coll, Hector
    Osorio-Leal, Yuliana
    Escobar-Builes, Maria Victoria
    Cardona-Castro, Nora
    TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 2022, 116 (05) : 501 - 508
  • [8] Pathogen-Specific Epitopes as Epidemiological Tools for Defining the Magnitude of Mycobacterium leprae Transmission in Areas Endemic for Leprosy
    Martins, Marcia V. S. B.
    Guimaraes, Marjorie M. da S.
    Spencer, John S.
    Hacker, Mariana A. V. B.
    Costa, Luciana S.
    Carvalho, Fernanda M.
    Geluk, Annemieke
    van der Ploeg-van Schip, Jolien J.
    Pontes, Maria A. A.
    Goncalves, Heitor S.
    de Morais, Janvier P.
    Bandeira, Tereza J. P. G.
    Pessolani, Maria C. V.
    Brennan, Patrick J.
    Pereira, Geraldo M. B.
    PLOS NEGLECTED TROPICAL DISEASES, 2012, 6 (04):
  • [9] Social and environmental conditions related to Mycobacterium leprae infection in children and adolescents from three leprosy endemic regions of Colombia
    Héctor Serrano-Coll
    Hugo Rene Mora
    Juan Camilo Beltrán
    Malcolm S. Duthie
    Nora Cardona-Castro
    BMC Infectious Diseases, 19
  • [10] High allele discrimination in the typing of single nucleotide polymorphisms of miRNA
    Takei, Fumie
    Akiyama, Misaki
    Dateki, Minori
    BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 46
12345