Adult Stem Cell Transplantation in Stroke: Its Limitations and Prospects

被引:29
|
作者
Roh, Jae-Kyu [1 ]
Jung, Keun-Hwa [1 ]
Chu, Kon [1 ]
机构
[1] Seoul Natl Univ Hosp, Dept Neurol, Stroke & Neural Stem Cell Lab, Stem Cell Res Ctr,Clin Res Inst, Seoul 110744, South Korea
关键词
Stroke; adult stem cell; clinical application; bone marrow; peripheral blood; adipose tissue; skeletal muscle; olfactory mucosa;
D O I
10.2174/157488808785740352
中图分类号
Q813 [细胞工程];
学科分类号
摘要
A growing number of studies have demonstrated stem cell-based therapy provides a feasible, realistic approach to the restoration of lost brain function after stroke. Moreover, adult stem cells may provide more appropriate clinical strategies. Leading candidate sources include bone marrow, peripheral blood, adipose tissue, skeletal muscle, and olfactory mucosa, which act as central repositories for multipotent stem cells that can repopulate neural tissues. The medical society is currently enthusiastic concerning the clinical applications of autologous adult stem cells in stroke, based on promising results obtained during experimental studies and initial clinical trials. However, before embracing clinical applications, several essential precautions must be properly addressed. For example, the regenerative potentials of adult stem cells decline with age, and stem cells isolated from aged patients may retain dysfunctional characteristics. Are the natures and amounts of available autologous cells appropriate for therapeutic application in stroke? Do transplanted cells remain functional in the diseased brain, and if so what are the optimal injection routes, cell doses, and timings? Thus, we believe that success in future clinical trials will depend on careful investigation at the experimental level, to allow us to understand not only the practicalities of stem cell use, but also the underlying biological principles involved. Here, we review the advantages and disadvantages of the different adult stem cell sources and discuss the challenges that must be negotiated to achieve transplantation success.
引用
收藏
页码:185 / 196
页数:12
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