Male breast cancer: Pathological and immunohistochemical features

Background: Male breast cancer is uncommon and studies regarding the potential clinical relevance of the histopathological and immunohistochemical features are infrequently reported. Materials and Methods. We investigated the biological characteristics of forty-one male patients with invasive breast cancer by assessing histopathological and multiple immunohistochemical features. Results. The majority wets no special type (ductal) (37/41), lobular cancer was not seen. 73% were histological grade 3, 93% were positive for oestrogen receptor and 73% for progesterone receptor. The proportion of cancers positive for c-erbB-2 (45%), EGFR (20%), p53 (58%), MiB1 (40%), NCRC11 (78%), were similar to reports for female breast cancer. Nonsignificant associations between pool survival outcome and grade 3 tumours, and positive tissue staining for MiB1 and p53 were seen. Conclusions. While there are similarities in the biological features of breast cancel in males and females, some differences were identified Male breast cancer is more likely to be grade 3 tumours and hormone receptor positive.