4-Aminosalicylic Acid Adducts

被引：36
|
作者：
Cherukuvada, Suryanarayan [1 ]
Bolla, Geetha [1 ]
Sikligar, Kanishka [2 ,3 ]
Nangia, Ashwini [1 ]
机构：
[1] Univ Hyderabad, Sch Chem, Hyderabad 500046, Andhra Pradesh, India
[2] Univ Hyderabad, Sch Chem, Networking Resource Ctr, Hyderabad 500046, Andhra Pradesh, India
[3] Bhaskar Pharm Coll, Hyderabad 500075, Andhra Pradesh, India
来源：
CRYSTAL GROWTH & DESIGN | 2013年 / 13卷 / 04期
关键词：
CRYSTAL-STRUCTURE PREDICTION; PARA-AMINOSALICYLIC ACID; GRAPH-SET ANALYSIS; COCRYSTAL CONTINUUM; CARBOXYLIC-ACIDS; MOLECULAR SALTS; POLYMORPHS; FORMS; STATE; MECHANOCHEMISTRY;
D O I：
10.1021/cg301798s
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
4-Aminosalicylic acid (p-aminosalicylic acid, PAS), an antituberculosis drug, is a model active pharmaceutical ingredient to study salt and cocrystal formation in a multiple hydrogen-bonding functionality molecule with carboxylic acid, amine, and phenol groups. A cytosine salt CYT+-PAS(-), salt cocrystal hydrate CWT+-PAS(-)-CYT-H2O, and nicotinamide cocrystal hydrate PAS-NAM-H2O, are described in this article. Furthermore, X-ray crystal structures of PAS sodium dihydrate, sulfate, and mesylate salts and dehydration/rehydration behavior of the sodium salt by powder X-ray diffraction are discussed.
引用
收藏
页码：1551 / 1557
页数：7
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