The evaluation of the metabolic and autonomic predictors of cardiovascular diseases in relation to prostatic hyperplasia symptoms

OBJECTIVES: High prevalence of cardiovascular diseases (CVD) is present in benign prostatic hyperplasia patients. Risk prediction models were developed for early identifi cation of these cardiovascular risks. We aimed to evaluate cardiovascular metabolic and autonomic predictors in relation to lower urinary tract symptoms' severity evaluated by the IPSS score.METHODS: This study included 318 healthy individuals recently diagnosed with benign prostate hyperplasia (BPH). Laboratory tests including metabolic, hormonal and infl ammatory markers were recorded. The cardiovascular risk indices like the atherogenic index of plasma and the triglyceride glucose index were calculated. The heart rate recovery after graded exercise was calculated.RESULTS: There was a signifi cant positive correlation between the IPSS score and both the atherogenic and the triglyceride glucose indices (r=0.388, p < 0.01 and r=0.109, p=0.032, respectively). IPSS score was also signifi cantly negatively correlated with heart rate recovery specially at the 3rd minute after exercise (r=-0.547, p < 0.01). On the other hand, the IPSS score had a signifi cant positive correlation with the infl ammatory markers and a signifi cant negative correlation with serum testosterone levels.CONCLUSIONS: Our study results suggest the presence of a combination of hormonal and infl ammatory changes in BPH patients affecting the severity of lower urinary tract symptoms (LUTS) which is correlated with metabolic and autonomic parameters that can predict an increased risk of CVD (Tab. 3, Ref. 47). Text in PDF www.elis.sk