Asymmetric protonation of lithium enolate of α-amino acid derivatives using chiral Bronsted acids

被引：0

作者：

Yanagisawa, A

Matsuzaki, Y

Yamamoto, H ^{[1
]}

机构：

[1] Nagoya Univ, CREST, Japan Sci & Technol Corp, Grad Sch Engn,Chikusa Ku, Nagoya, Aichi 4648603, Japan

[2] Chiba Univ, Fac Sci, Dept Chem, Chiba 2638522, Japan

来源：

SYNLETT | 2001年 / 12期

关键词：

enantioselective protonation; lithium enolate; alpha-amino acid derivative; chiral alcohols; 2-oxazoline; asymmetric catalysis;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chiral alcohols possessing an asymmetric 2-oxazoline ring were synthesized as new chiral Bronsted acids from tetrahydro-2-furoic acid and (IS, 2R)-2-amino-1,2-diphenylethanol. These alcohols were superior to (S,S)- or (R,R)-imide reported previously as a chiral proton source for enantioselective protonation of lithium enolate of,in alanine derivative.

引用

页码：1855 / 1858

页数：4

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