In this brief report, the authors investigate how different types of parental racial-ethnic socialization messages (i.e., cultural socialization/pluralism, promotion of mistrust, and preparation for racial bias) moderate the relationship between racial discrimination and psychological distress in a sample of 187 Asian American adolescents. Results indicated a significant positive relationship between racial discrimination and psychological distress. Cultural socialization/pluralism and promotion of mistrust also moderated the racial discrimination and psychological distress link. Specifically, for adolescents reporting low frequencies of cultural socialization/pluralism messages, discrimination was positively associated with psychological distress, suggesting cultural socialization/pluralism messages may be a protective factor. Discrimination was also positively associated with psychological distress for adolescents reporting high frequencies of promotion of mistrust, suggesting that promotion of mistrust may be a risk factor. Overall, the findings emphasize the important role that racial-ethnic socialization messages can have on psychological distress among Asian American adolescents who experience racial discrimination.