Use of anakinra in severe COVID-19: A case report

被引：55
|
作者：
Filocamo, Giovanni [1 ]
Mangioni, Davide [1 ,2 ,3 ]
Tagliabue, Paola [1 ,4 ]
Aliberti, Stefano [1 ,2 ,5 ,6 ]
Costantino, Giorgio [1 ,2 ,7 ]
Minoia, Francesca [1 ,8 ]
Bandera, Alessandra [1 ,2 ,3 ]
机构：
[1] Osped Maggiore Policlin, Fdn IRCCS Ca Granda, Milan, Italy
[2] Univ Milan, Milan, Italy
[3] Univ Milan, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Dept Internal Med, Infect Dis Unit,Dept Pathophysiol & Transplantat, Via Francesco Sforza 35, I-20122 Milan, Italy
[4] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Anesthesia Reanimat & Urgent Emergency Care, Via Francesco Sforza 35, I-20122 Milan, Italy
[5] Univ Milan, Internal Med Dept, Dept Pathophysiol & Transplantat, Resp Unit, Via Francesco Sforza 35, I-20122 Milan, Italy
[6] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Cyst Fibrosis Adult Ctr, Via Francesco Sforza 35, I-20122 Milan, Italy
[7] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Unita Operat Complessa Pronto Soccorso & Med Urge, Via Francesco Sforza 35, I-20122 Milan, Italy
[8] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Pediat Medium Intens Care Unit, Pediat Rheumatol, Clin Marchi, Via Commenda 9, I-20123 Milan, Italy
来源：
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | 2020年 / 96卷
关键词：
Anakinra; IL-1; COVID-19; Treatment; Biologic;
D O I：
10.1016/j.ijid.2020.05.026
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Coronavirus disease 19 is a global healthcare emergency with a high lethality rate. Relevant inflammatory cytokine storm is associated with severity of disease, and IL-1 inhibition is a cornerstone treatment for hyperinflammatory diseases. We present here the case of a patient with critical COVID-19 successfully treated with IL-1 receptor antagonist (anakinra). (C) 2020 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
引用
收藏
页码：607 / 609
页数：3
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