Ovariectomized transgenic mice expressing hepatitis C virus polyprotein develop hepatic steatosis through inactivation of AMPK/PGC1α signaling pathway

被引:0
|
作者
Tomiyama, Yasuyuki [1 ]
Nishina, Sohji [1 ]
Hara, Yuichi [1 ]
Hino, Keisuke [1 ]
机构
[1] Kawasaki Med Sch, Kurashiki, Okayama, Japan
关键词
D O I
暂无
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
2030
引用
收藏
页码:1189A / 1190A
页数:2
相关论文
共 50 条
  • [1] IRON OVERLOAD CAUSES HEPATIC STEATOSIS THROUGH THE ENDOPLASMIC RETICULUM STRESS IN TRANSGENIC MICE EXPRESSING THE HEPATITIS C VIRUS POLYPROTEIN
    Nishina, Sohiji
    Korenaga, Masaaki
    Hidaka, Isao
    Sakai, Aya
    Shinozaki, Akane
    Sakaida, Isao
    Hino, Keisuke
    HEPATOLOGY, 2008, 48 (04) : 773A - 773A
  • [2] Iron overload develops in the absence of hepatic inflammation in transgenic mice expressing the hepatitis C virus polyprotein
    Nishina, S
    Hino, K
    Hidaka, I
    Furutani, T
    Yamaguchi, Y
    Korenaga, M
    Okuda, M
    Lemon, SM
    Okita, K
    HEPATOLOGY, 2005, 42 (04) : 557A - 558A
  • [3] Decrease in hepcidin is essential for hepatic iron overload in transgenic mice expressing the hepatitis C virus polyprotein
    Hino, Keisuke
    Korenaga, Masaaki
    Hidaka, Isao
    Okuda, Michiari
    Yamaguchi, Yuhki
    Sakaida, Isao
    HEPATOLOGY, 2006, 44 (04) : 303A - 303A
  • [4] Hepatic iron overload induces hepatocellular carcinoma in transgenic mice expressing the hepatitis C virus polyprotein
    Furutani, Takakazu
    Hino, Keisuke
    Okuda, Michiari
    Gondo, Toshikazu
    Nishina, Sohji
    Kitase, Akira
    Korenaga, Masaaki
    Xiao, Shu-Yuan
    Weinman, Steven A.
    Lemon, Stanley M.
    Lemon, Stanley M.
    Sakaida, Isao
    Okita, Kiwamu
    GASTROENTEROLOGY, 2006, 130 (07) : 2087 - 2098
  • [5] Cosupplementation with vitamin E and coenzyme Q(10) reduces iron-overloaded induced hepatic steatosis in transgenic mice expressing the hepatitis C virus polyprotein
    Korenaga, Masaaki
    Nishina, Sohji
    Hino, Keisuke
    Sakaida, Isao
    HEPATOLOGY, 2007, 46 (04) : 467A - 468A
  • [6] Impaired clearance of virus-infected hepatocytes in transgenic mice expressing the hepatitis C virus polyprotein
    Disson, O
    Haouzi, D
    Desagher, S
    Loesch, K
    Hahne, M
    Kremer, EJ
    Jacquet, C
    Lemon, SM
    Hibner, U
    Lerat, H
    GASTROENTEROLOGY, 2004, 126 (03) : 859 - 872
  • [7] Xyloketal B Reverses Nutritional Hepatic Steatosis, Steatohepatitis, and Liver Fibrosis through Activation of the PPARα/PGC1α Signaling Pathway
    Tong, Yichen
    Zhu, Wentao
    Wen, Tianzhi
    Mukhamejanova, Zere
    Xu, Fang
    Xiang, Qi
    Pang, Jiyan
    JOURNAL OF NATURAL PRODUCTS, 2022, : 1738 - 1750
  • [8] Mechanisms of hepatitis C virus (HCV)-induced hepatic steatosis in transgenic mice
    Lerat, H.
    Foufelle, F.
    Pawlotsky, J-M.
    JOURNAL OF HEPATOLOGY, 2007, 46 : S9 - S10
  • [9] Hepatitis C virus core protein induces hepatic steatosis in transgenic mice
    Moriya, K
    Yotsuyanagi, H
    Shintani, Y
    Fujie, H
    Ishibashi, K
    Matsuura, Y
    Miyamura, T
    Koike, K
    JOURNAL OF GENERAL VIROLOGY, 1997, 78 : 1527 - 1531
  • [10] Susceptibility to oxidative stress and resistance to apoptosis in transgenic mice expressing the hepatitis C virus polyprotein.
    Furutani, T
    Hino, K
    Okuda, M
    Hara, YI
    Hidaka, I
    Ando, M
    Yamaguchi, Y
    Chan, TS
    Lemon, SM
    Okita, K
    HEPATOLOGY, 2004, 40 (04) : 374A - 375A