Key Non-Metal Ingredients for Cu-catalyzed "Click" Reactions in Glycerol: Nanoparticles as Efficient Forwarders

被引：18

作者：

Rodriguez-Rodriguez, Marta ^{[1
,2
,3
]}

Llanes, Patricia ^{[3
]}

Pradel, Christian ^{[1
,2
]}

Pericas, Miguel A. ^{[3
]}

Gomez, Montserrat ^{[1
,2
]}

机构：

[1] UPS, LHFA, 118 Route Narbonne, F-31062 Toulouse 9, France

[2] Univ Toulouse, CNRS UMR 5069, 118 Route Narbonne, F-31062 Toulouse 9, France

[3] Barcelona Inst Sci & Technol, Inst Chem Res Catalonia ICIQ, Avda Paisos Catalans 16, Tarragona 43007, Spain

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2016年 / 22卷 / 50期

关键词：

azide-alkyne cycloaddition; copper; glycerol; long-chain amines; nanoparticles; AZIDE-ALKYNE CYCLOADDITION; RUTHENIUM NANOPARTICLES; PALLADIUM NANOPARTICLES; IONIC LIQUIDS; LIGANDS; COPPER; COORDINATION; COMPLEXES; CHEMISTRY; CUAAC;

D O I：

10.1002/chem.201604048

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The effect of long-alkyl-chain amines in Cu-I-assisted azide-alkyne cycloadditions of terminal alkynes with organic azides in glycerol and other environmentally benign solvents (water, ethanol) has been examined. The presence of these additives favors the in situ formation of Cu-I-based nanoparticles and results in an increase of the catalytic reactivity. In glycerol, liquid-phase transmission electron microscopy (TEM) analyses, enabled by the negligible vapor pressure of this solvent, proved that Cu-I nanoparticles are responsible for the observed catalytic activity. The wide variety of alkynes and azides of which this effect has been investigated (14 combinations) confirms the role played by these additives in Cu-catalyzed Huisgen cycloadditions.

引用

页码：18247 / 18253

页数：7

共 25 条

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