Dirhodium(II) tetrakis[N-benzene-fused phthaloyl-(S)piperidinonate] as a chiral Lewis acid:: Catalytic enantioselective aldol reactions of acetate-derived silylketene acetals and aldehydes

被引：0

作者：

Washio, T ^{[1
]}

Nakamura, S ^{[1
]}

Anada, M ^{[1
]}

Hashimoto, S ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan

来源：

HETEROCYCLES | 2005年 / 66卷

关键词：

aldo reaction; asymmetric catalysis; enantioselection; dirhodium(II) complex; sily ketne acetal;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A first example of chiral dirhodium(II) complex-catalyzed enantioselective Mukaiyama aldol reactions is described. The aldol addition reaction of methyl acetate-derived trimethylsilylketene acetal with specific aldehydes such as benzyloxyacetaldehyde and electron-poor aromatic aldehydes is effectively catalyzed by dirhodium(II) tetrakis[N-benzene-fused phthaloyl-(S)piperidinonate] (1a), providing silylated aldol adducts in up to 94% ee.

引用

页码：567 / 578

页数：12