Effect of Cordycepin Purified from Cordyceps militaris on Th1 and Th2 Cytokines in Mouse Splenocytes

被引：26

作者：

Jeong, Min-Ho ^{[2
,3
]}

Seo, Min Jeong ^{[3
,4
]}

Park, Jeong Uck ^{[3
]}

Kang, Byoung Won ^{[3
]}

Kim, Kyoung-Sook ^{[3
]}

Lee, Jae Yun ^{[5
]}

Kim, Gi-Young ^{[6
]}

Kim, Jung-In ^{[7
]}

Choi, Yung Hyun ^{[8
]}

Kim, Kwang Hyuk ^{[1
]}

Jeong, Yong Kee ^{[2
,3
]}

机构：

[1] Kosin Univ, Coll Med, Dept Microbiol, Pusan 602708, South Korea

[2] Dong A Univ, Coll Med, Dept Microbiol, Pusan 602714, South Korea

[3] Dong A Univ, Medi Farm Ind Res Ctr, Pusan 604714, South Korea

[4] Dong A Univ, Dept Biotechnol, Pusan 604714, South Korea

[5] Cheongweon Ind Farm, Gimhae 621747, South Korea

[6] Jeju Natl Univ, Dept Marine Life Sci, Immunobiol Lab, Cheju 690756, South Korea

[7] Inje Univ, Sch Food & Life Sci, Gimhae 621749, South Korea

[8] Dong Eui Univ, Coll Oriental Med, Dept Biochem, Pusan 614050, South Korea

来源：

JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | 2012年 / 22卷 / 08期

关键词：

Cordycepin; Cordyceps militaris; IL-4; IL-10; IL-12; INTERFERON-GAMMA; 3'-DEOXYADENOSINE; INHIBITION; CELLS;

D O I：

10.4014/jmb.1203.03039

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Cordycepin was purified from a mushroom, Cordyceps millions, and its effect on Th1 and Th2 cytokines was examined. The level of cytokine induction in mouse splenocytes was estimated after co-inoculation of purified cordycepin and LPS. When 5 mu g/ml of purified cordycepin was exposed to mouse splenocytes for 72 h, the level of a Th1 cytokine IL-12 increased by 2.9-fold. The addition of the purified cordycepin to splenocytes also increased the level of Th2 cytokines, IL-4 and IL-10, by 1.9- and 1.8-fold, respectively. Therefore, cordycepin increases the cytokine levels and may contribute to the up-regulation of cellular and humoral immunity.

引用

页码：1161 / 1164

页数：4

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