MiR-29b Exerts Anti-Multiple Myeloma Activity by Targeting Key Oncogenic Pathways and Modulating DNA Methylation Profile.

被引：0
|
作者：
Amodio, Nicola [1 ]
Di Martino, Maria Teresa [1 ,2 ]
Foresta, Umberto [1 ,2 ]
Rossi, Marco [1 ,2 ]
Leotta, Marzia [1 ,2 ]
Leone, Emanuela [1 ]
Lionetti, Marta [3 ,4 ]
Gulla, Annamaria [1 ,2 ]
D'Aquila, Patrizia [5 ]
Bellizzi, Dina [5 ]
Passarino, Giuseppe [5 ]
Fabiani, Fernanda [6 ]
Fulciniti, Mariateresa [7 ,8 ]
Ferrarini, Manlio [9 ]
Morabito, Fortunato [10 ]
Neri, Antonino [3 ,4 ]
Munshi, Nikhil C. [7 ,8 ]
Anderson, Kenneth C.
Tagliaferri, Pierosandro [1 ,2 ]
Tassone, Pierfrancesco [1 ,2 ]
机构：
[1] Magna Graecia Univ Catanzaro, Catanzaro, Italy
[2] T Campanella Canc Ctr, Catanzaro, Italy
[3] Fdn Ca Granda IRCCS Osped Maggiore Policlin, Hematol BMT Unit, Milan, Italy
[4] Univ Milan, Milan, Italy
[5] Univ Calabria, Dept Cell Biol, I-87036 Cosenza, Italy
[6] Magna Graecia Univ Catanzaro, Catanzaro, Italy
[7] Harvard Univ, Sch Med, Dana Farber Canc Inst, LeBow Inst Myeloma Therapeut, Boston, MA 02115 USA
[8] Harvard Univ, Sch Med, Dana Farber Canc Inst, Jerome Lipper Ctr Multiple Myeloma Res, Boston, MA 02115 USA
[9] IST, Natl Inst Canc Res, Med Oncol Dept C, Genoa, Italy
[10] Hosp Cosenza, Dept Oncohematol, Cosenza, Italy
来源：
BLOOD | 2012年 / 120卷 / 21期
关键词：
D O I：
10.1182/blood.V120.21.2941.2941
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
2941
引用
收藏
页数：2
相关论文
共 16 条
  • [1] DNA-demethylating and anti-tumor activity of synthetic miR-29b mimics in multiple myeloma
    Amodio, Nicola
    Leotta, Marzia
    Bellizzi, Dina
    Di Martino, Maria Teresa
    D'Aquila, Patrizia
    Lionetti, Marta
    Fabiani, Fernanda
    Leone, Emanuela
    Gulla, Anna Maria
    Passarino, Giuseppe
    Caraglia, Michele
    Negrini, Massimo
    Neri, Antonino
    Giordano, Antonio
    Tagliaferri, Pierosandro
    Tassone, Pierfrancesco
    ONCOTARGET, 2012, 3 (10) : 1246 - 1258
  • [2] Therapeutic Targeting of miR-29b/HDAC4 Epigenetic Loop in Multiple Myeloma
    Amodio, Nicola
    Stamato, Maria Angelica
    Guila, Anna Maria
    Morelli, Eugenio
    Romeo, Enrica
    Raimondi, Lavinia
    Pitari, Maria Rita
    Ferrandino, Ida
    Misso, Gabriella
    Caraglia, Michele
    Perrotta, Ida
    Neri, Antonino
    Fulciniti, Mariateresa
    Rolfo, Christian
    Anderson, Kenneth C.
    Munshi, Nikhil C.
    Tagliaferri, Pierosandro
    Tassone, Pierfrancesco
    MOLECULAR CANCER THERAPEUTICS, 2016, 15 (06) : 1364 - 1375
  • [3] MiR-29b Counteracts Aberrant HDAC4 Expression and Enhances Vorinostat Activity in Multiple Myeloma
    Amodio, Nicola
    Leotta, Marzia
    Gulla, Anna Maria
    Raimondi, Lavinia
    Morelli, Eugenio
    Stamato, Maria Angelica
    Calimeri, Teresa
    Di Martino, Maria Teresa
    Rossi, Marco
    Leone, Emanuela
    Neri, Antonino
    Tagliaferri, Pierosandro
    Tassone, Pierfrancesco
    BLOOD, 2014, 124 (21)
  • [4] LNA -Gapmer Antisense Oligonucleotides Targeting the Oncogenic Lncrna MALAT1 Trigger Anti-Multiple Myeloma Activity By Proteasome Blockade
    Amodio, Nicola
    Stamato, Maria Angelica
    Juli, Giada
    Morelli, Eugenio
    Manzoni, Martina
    Taiana, Elisa
    Rossi, Marco
    Arbitrio, Mariamena
    Fulciniti, Mariateresa
    Munshi, Nikhil
    Neri, Antonino
    Tagliaferri, Pierosandro
    Tassone, Pierfrancesco
    BLOOD, 2017, 130
  • [5] Selective G-Protein Estrogen Receptor (GPER) Activation Triggers Anti-Multiple Myeloma Activity and Synergizes with MiR-29b-Inducing Drugs
    Amodio, Nicola
    Leotta, Marzia
    Morelli, Eugenio
    Calimeri, Teresa
    Gulla, Anna Maria
    Stamato, Maria Angelica
    Romeo, Enrica
    Foresta, Umberto
    Neri, Antonino
    Di Martino, Maria Teresa
    Tagliaferri, Pierosandro
    Tassone, Pierfrancesco
    BLOOD, 2014, 124 (21)
  • [6] Cucurbitacin B exerts anti-cancer activities in human multiple myeloma cells in vitro and in vivo by modulating multiple cellular pathways
    Yang, Tai
    Liu, Jin
    Yang, Mali
    Huang, Ning
    Zhong, Yueling
    Zeng, Ting
    Wei, Rong
    Wu, Zhongjun
    Xiao, Cui
    Cao, Xiaohua
    Li, Minhui
    Li, Limei
    Han, Bin
    Yu, Xiaoping
    Li, Hua
    Zou, Qiang
    ONCOTARGET, 2017, 8 (04) : 5800 - 5813
  • [7] MiR-29b antagonizes the pro-inflammatory tumor-promoting activity of multiple myeloma-educated dendritic cells
    C Botta
    M Cucè
    M R Pitari
    D Caracciolo
    A Gullà
    E Morelli
    C Riillo
    L Biamonte
    M E Gallo Cantafio
    R Prabhala
    C Mignogna
    A Di Vito
    E Altomare
    N Amodio
    M T Di Martino
    P Correale
    M Rossi
    A Giordano
    N C Munshi
    P Tagliaferri
    P Tassone
    Leukemia, 2018, 32 : 1003 - 1015
  • [8] C6-ceramide treatment inhibits the proangiogenic activity of multiple myeloma exosomes via the miR-29b/Akt pathway
    Liping Liu
    Qinmao Ye
    Langni Liu
    Ji Chen Bihl
    Yanfang Chen
    Jing Liu
    Qian Cheng
    Journal of Translational Medicine, 18
  • [9] MiR-29b antagonizes the pro-inflammatory tumor-promoting activity of multiple myeloma-educated dendritic cells
    Botta, C.
    Cuce, M.
    Pitari, M. R.
    Caracciolo, D.
    Gulla, A.
    Morelli, E.
    Riillo, C.
    Biamonte, L.
    Cantafio, M. E. Gallo
    Prabhala, R.
    Mignogna, C.
    Di Vito, A.
    Altomare, E.
    Amodio, N.
    Di Martino, M. T.
    Correale, P.
    Rossi, M.
    Giordano, A.
    Munshi, N. C.
    Tagliaferr, P.
    Tassone, P.
    LEUKEMIA, 2018, 32 (04) : 1003 - 1015
  • [10] C6-ceramide treatment inhibits the proangiogenic activity of multiple myeloma exosomes via the miR-29b/Akt pathway
    Liu, Liping
    Ye, Qinmao
    Liu, Langni
    Bihl, Ji Chen
    Chen, Yanfang
    Liu, Jing
    Cheng, Qian
    JOURNAL OF TRANSLATIONAL MEDICINE, 2020, 18 (01)
12